... that met our prioritization criteria included FAM129B and CERCAM on chromosome 9 and SYT1, GNAO1, and CDH3 on chromosome 16. National Institutes of Health (NIH) 10.13039/100000002 Genetic heterogeneity Genetics Association Family-based association study Complex disease Idiopathic...

..., and c Dalla Lana School of Public Health, University of Toronto, Toronto, Ont., Canada Key Words Evidential paradigm Likelihood Parametric linkage Complex disease Abstract Multipoint (MP) linkage analysis represents a valuable tool for whole-genome studies but suffers from the disadvantage...

... Key Words Family-based association Maternal-fetal genotype test Extended maternal-fetal genotype test Genotype interactions Complex disease Olfactory deficits Gene-by-gene Gene-by-environment Major histocompatibility complex Abstract Background and Methods: Association studies using...

..., Research Triangle Park, N.C., USA Key Words Gene-environment interaction Genome-wide scan Meta-analysis Case-control association analysis Complex disease genes with subtle gene-environment interaction patterns. Conclusion: The joint meta-analysis is an attractive approach to discover markers which...

... mapping of the common complex diseases analyzed. In addition, we found that the polygenic random component might absorb the effects of some covariates usually considered in the risk evaluation, such as gender, age and BMI. © 2008 S. Karger AG, Basel 2009 Copyright / Drug Dosage / Disclaimer...

... by keratinocyte hyperproliferation and altered differentiation. Atopic dermatitis (ATOD) is a chronic inflammatory, pruritic and eczematous disease frequently associated with respiratory atopy. These diseases are associated with distinct immunologic abnormalities and represent typical examples of complex diseases...

... on the marginal effects of single-locus and tend to ignore the multigenic nature of complex diseases. The increasing request for localizing genes underlying traits in multi-gene diseases has led to the development of some statistical methods. In this study, we develop a multi-locus analysis method – multi-locus...

... to detect predisposing genes. We present a new approach based on Mantel statistics for spacetime clustering, which is developed in order to improve the power of haplotype sharing analysis for gene mapping in complex disease. Methods: The new statistic correlates genetic similarity and phenotypic similarity...

...L. Bastone; M. Reilly; D.J. Rader; A.S. Foulkes Complex diseases such as cardiovascular disease are likely due to the effects of high-order interactions among multiple genes and demographic factors. Therefore, in order to understand their underlying biological mechanisms, we need to consider...

.... Terwilliger JD: Genetic epidemiology and circumpolar population isolates – The ‘Finland’ of complex disease? Abstract to Securing Northern Futures. Canadian Circumpolar Institute, Edmonton 1997. 50. Andersen S: Greenland medical bibliography. Arctic Med Res 1981;29:1–137. 51. Curtis T, Bjerregaard P...