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Keywords: COPD
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Journal Articles
Beyond GWAS in COPD: Probing the Landscape between Gene-Set Associations, Genome-Wide Associations and Protein-Protein Interaction Networks
Available to PurchaseSubject Area:
Genetics
Merry-Lynn Noelle McDonald, Manuel Mattheisen, Michael H. Cho, Yang-Yu Liu, Benjamin Harshfield, Craig P. Hersh, Per Bakke, Amund Gulsvik, Christoph Lange, Terri H. Beaty, Edwin K. Silverman, on behalf of the GenKOLS, COPDGene and ECLIPSE study investigators
Journal:
Human Heredity
Hum Hered (2015) 78 (3-4): 131–139.
Published Online: 27 August 2014
... approach to integrate genotype and protein-protein interaction (PPI) data to identify disease network modules associated with chronic obstructive pulmonary disease (COPD) and to perform traditional pathway analysis. Methods: We utilized a standard gene-set association approach (FORGE) using gene-based...
Journal Articles
Linkage Analysis of Alpha 1-Antitrypsin Deficiency: Lessons for Complex Diseases
Available to PurchaseSubject Area:
Genetics
Edwin K. Silverman, Jonathan D. Mosley, D.C. Rao, Lyle J. Palmer, Michael A. Province, Robert C. Elston, Scott T. Weiss, Edward J. Campbell
Journal:
Human Heredity
Hum Hered (2001) 52 (4): 223–232.
Published Online: 12 November 2001
...Edwin K. Silverman; Jonathan D. Mosley; D.C. Rao; Lyle J. Palmer; Michael A. Province; Robert C. Elston; Scott T. Weiss; Edward J. Campbell Objectives: Severe alpha 1-antitrypsin (A1AT) deficiency is the one proven genetic risk factor for chronic obstructive pulmonary disease (COPD). Familial...