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1-20 of 21
Keywords: Association studies
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Journal Articles
Subject Area:
Genetics
Journal:
Human Heredity
Hum Hered (2016) 80 (3): 144–152.
Published Online: 25 June 2016
...Huanhuan Zhu; Shuanglin Zhang; Qiuying Sha Background/Aims: Genome-wide association studies (GWAS) have identified many variants that each affect multiple phenotypes, which suggests that pleiotropic effects on human complex phenotypes may be widespread. Therefore, statistical methods that can...
Journal Articles
Subject Area:
Genetics
Journal:
Human Heredity
Hum Hered (2010) 69 (3): 171–183.
Published Online: 05 January 2010
...Gina M. D’Angelo; M. Ilyas Kamboh; Eleanor Feingold Missing genotype data in a candidate gene association study can make it difficult to model the effects of multiple genetic variants simultaneously. In particular, when regression models are used to model phenotype as a function of SNP genotypes...
Journal Articles
Subject Area:
Genetics
Journal:
Human Heredity
Hum Hered (2009) 68 (2): 73–86.
Published Online: 09 April 2009
... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Linkage HapMap Finite sample error Association studies...
Journal Articles
Subject Area:
Genetics
Journal:
Human Heredity
Hum Hered (2009) 67 (2): 104–115.
Published Online: 12 December 2008
... is usually low. Testing for deviations from HWE in parental and unaffected sibling genotype data is still beneficial for quality control even though functional loci, in parental and unaffected sibling genotype data, can produce an association signal. Association studies Data quality control Family...
Journal Articles
Subject Area:
Genetics
Journal:
Human Heredity
Hum Hered (1990) 40 (3): 190–192.
Published Online: 02 September 2008
..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Genetic markers Selection Association studies Hum Hered 1990;40:190-192 ©...
Journal Articles
Subject Area:
Genetics
Journal:
Human Heredity
Hum Hered (2007) 65 (3): 166–174.
Published Online: 16 October 2007
...) (T R ) and the haplotype-based test (T H ). Results of these comparisons show that our proposed combining procedure (T C ) is preferred in all scenarios examined. We also apply this new test to a data set from a previously reported association study on airway responsiveness to methacholine. Original...
Journal Articles
Subject Area:
Genetics
Journal:
Human Heredity
Hum Hered (2007) 64 (4): 243–249.
Published Online: 22 June 2007
...) 10.13039/100000002 Association studies tagSNP LD structure Imputed functional score Factor analysis © 2007 S. Karger AG, Basel 2007 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced...
Journal Articles
Subject Area:
Genetics
Journal:
Human Heredity
Hum Hered (2007) 64 (3): 149–159.
Published Online: 25 May 2007
...Prakash Gorroochurn; Susan E. Hodge; Gary A. Heiman; David A. Greenberg The HapMap project has given case-control association studies a unique opportunity to uncover the genetic basis of complex diseases. However, persistent issues in such studies remain the proper quantification of, testing...
Journal Articles
Subject Area:
Genetics
Journal:
Human Heredity
Hum Hered (2007) 64 (1): 63–73.
Published Online: 27 April 2007
...V. Moskvina; M.C. O’Donovan Objectives: Genetic association studies are usually based upon restricted sets of ‘tag’ markers selected to represent the total sequence variation. Tag selection is often determined by some threshold for the r 2 coefficients of linkage disequilibrium (LD) between tag...
Journal Articles
Subject Area:
Genetics
Journal:
Human Heredity
Hum Hered (2007) 64 (1): 27–34.
Published Online: 27 April 2007
..., University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, and bInstitute of Informatics, Humboldt University, Berlin, Germany Key Words Association studies Entropy HapMap project Information Linkage disequilibrium Population history Single nucleotide polymorphism Tagging...
Journal Articles
Subject Area:
Genetics
Journal:
Human Heredity
Hum Hered (2007) 63 (2): 85–92.
Published Online: 02 February 2007
... the cornerstone of genome association studies with tagSNPs. The interactive effect of two variants is only tested once the individual effect of one variant is detected. Both genes, however, may have at the same time a weak (or even no) marginal effect but an important effect through their interaction...
Journal Articles
Subject Area:
Genetics
Journal:
Human Heredity
Hum Hered (2007) 63 (2): 93–100.
Published Online: 02 February 2007
... Medicine, and bDivision of Biostatistics, Washington University in St. Louis School of Medicine, St. Louis, Mo., USA Key Words Epistasis Gene-gene interactions Multilocus traits Association studies Abstract Background/Aims: Many diseases important to public health are not due solely to a single...
Journal Articles
Subject Area:
Genetics
Journal:
Human Heredity
Hum Hered (2006) 61 (4): 210–221.
Published Online: 08 September 2006
...M. Guedj; J. Wojcik; E. Della-Chiesa; G. Nuel; K. Forner Association studies are traditionally performed in the case-control framework. As a first step in the analysis process, comparing allele frequencies using the Pearson’s chi-square statistic is often invoked. However such an approach assumes...
Journal Articles
Subject Area:
Genetics
Sara C. Hamon, Sharon L.R. Kardia, Eric Boerwinkle, Kiang Liu, Kathy L.E. Klos, Andrew G. Clark, Charles F. Sing
Journal:
Human Heredity
Hum Hered (2006) 61 (2): 87–96.
Published Online: 15 June 2006
... Association studies Abstract Objective: Evaluate the consistency of the contribution of interactions between single nucleotide polymorphism (SNP) genotype e ects to variation in measures of lipid metabolism across ethnic strata within gender. Methods and Results: We considered 80 SNPs within...
Journal Articles
Subject Area:
Genetics
Journal:
Human Heredity
Hum Hered (2005) 60 (2): 97–108.
Published Online: 02 November 2005
...Taane G. Clark; Maria De Iorio; Robert C. Griffiths; Martin Farrall Large-scale association studies hold promise for discovering the genetic basis of common human disease. These studies will consist of a large number of individuals, as well as large number of genetic markers, such as single...
Journal Articles
Subject Area:
Genetics
Francisco M. de La Vega, Derek Gordon, Xiaoping Su, Charles Scafe, Hadar Isaac, Dennis A. Gilbert, Eugene G. Spier
Journal:
Human Heredity
Hum Hered (2005) 60 (1): 43–60.
Published Online: 16 September 2005
... association study of psoriasis. Results of our regression analysis indicate that four highly significant factors that determine average power to detect association are: disease model, average marker-marker disequilibrium, haplotype diversity, and the trait allele frequency. These findings may have important...
Journal Articles
Subject Area:
Genetics
Journal:
Human Heredity
Hum Hered (2005) 58 (3-4): 145–153.
Published Online: 21 March 2005
...Dvora Shmulewitz; Junying Zhang; David A. Greenberg Objective: Case-control association studies in mixed populations can result in spurious disease-marker associations if subpopulation disease prevalence and marker frequencies both differ. Genomic control (GC) uses neutral loci to correct...
Journal Articles
Subject Area:
Genetics
Journal:
Human Heredity
Hum Hered (2005) 58 (2): 73–81.
Published Online: 10 February 2005
... from any ideas, methods, instructions or products referred to in the content or advertisements. Rare observations Haplotype information Association studies Original Paper Hum Hered 2004;58:73 81 DOI: 10.1159/000083028 Received: November 20, 2003 Accepted after revision: October 13, 2004...
Journal Articles
Subject Area:
Genetics
Journal:
Human Heredity
Hum Hered (2004) 58 (1): 40–48.
Published Online: 13 December 2004
... that can occur with relatively low CRR values. Population stratification Association studies Type I error Bias Original Paper Hum Hered 2004;58:40 48 DOI: 10.1159/000081455 Received: April 20, 2004 Accepted after revision: August 6, 2004 Effect of Population Stratification on Case-Control...
Journal Articles
Subject Area:
Genetics
Journal:
Human Heredity
Hum Hered (2003) 56 (1-3): 18–31.
Published Online: 14 November 2003
... discusses this problem for both population – and family-based association studies. The role of the R 2 measure of association between a causal locus and various methods of scoring of marker haplotypes is highlighted. In most cases, the simplest method of scoring (locus coding), which does not require phase...
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