...Ramouna Fouladi; Kyrylo Bessonov; François Van Lishout; Kristel Van Steen Genome-wide association studies have revealed a vast amount of common loci associated to human complex diseases. Still, a large proportion of heritability remains unexplained. The extent to which rare genetic variants (RVs...

... to genome-wide association study (GWAS) data. This strategy first involves the identification of inbred individuals among cases using the genome-wide SNP data and then focuses on these inbred affected individuals and searches for genomic regions of shared homozygosity by descent that could harbor rare...

..., were genotyped with a high-density map of single nucleotide polymorphisms. Tests of linkage for fine-mapping and intra-familial tests of association, including tiled regression, were performed on scoliosis as both a qualitative and quantitative trait. Results and Conclusions: Nominally significant...

... disequilibrium (LD), or association analysis, in case-control data, trio data, and/or multiplex family data, with options for joint linkage and trait-marker LD or conditional LD given linkage; dichotomous trait, quantitative trait and quantitative trait threshold models; and certain types of gene-gene...

..., CRLMM and Birdseed, designed for the Affymetrix SNP Array 6.0. Methods: Various QC options were tried using the two algorithms and comparisons were made on subject and call rate and on association results using two data sets. Results: For Birdseed, we recommend using the contrast QC instead of QC call...

... 2 diabetes (T2DM). The objective of the present study is to determine whether genetic variation in OGG1 is associated with type 2 diabetes (T2DM) in a Mexican American cohort. Methods: Ten SNPs including two tagging SNPs (rs1052133, rs2072668) across the OGG1 gene region were selected from...

...K.F. Cheng; J.Y. Lee; J.H. Chen Population stratification (PS) is referred to the systematic difference in allele frequencies between subpopulations in a population. It could cause a false-positive conclusion in a case-control association study, where the association is due to the structure...

... analyses of a 10 cM genome scan in 820 multiplex CL/P families (6,565 individuals). Significant linkage results were followed by association analyses of 1,476 SNPs in candidate genes and regions, utilizing a weighted false discovery rate (wFDR) approach to control for multiple testing and incorporate...

...Mark M. Iles In assessing the power of an association study one needs to consider a variety of genetic models and to have some knowledge of the values of the relevant population parameters in those models. One’s comparison of different models should be made such that these parameters are equal...

...Beate Glaser; Peter Holmans Objectives: Combining the analysis of family-based samples with unrelated individuals can enhance the power of genetic association studies. Various combined analysis techniques have been recently developed; as yet, there have been no comparisons of their power...

... the bivariate distribution of association test statistics from pooled and individual genotypes. We used a sample of approximately 1,000 samples with individual and pooled genotyping on 40,000 SNPs. Results and Conclusions: We found that the distribution of the joint test statistics can be modelled as a mixture...

...Helena L.P. Franco; Denise M. Moreira; F.M. Salzano; S.E.B. Santos; Maria M. Conceição; H. Schneider No association between GLO and Hp was found in three Brazilian samples (153 Whites, 216 Blacks from Porto Alegre and 564 mixed individuals from Aracaju). In a sample of 174 Blacks (settled along...

...Ewa Raczek; Jadwiga Kabiesz Among 1,239 unrelated adults from Upper Silesia (Poland), a significant association between ESD and C3 phenotypes was found. This is in accordance with the results obtained in an Indian population. 23 12 1993 21 07 1994 3 9 2008 Esterase D...

...Fabio Macciardi; Massimiliano Verga; James L. Kennedy; Arturas Petronis; Giuseppe Bersani; Paolo Pancheri; Enrico Smeraldi Our work investigates the relationship between genetic factors and schizophrenia, seeking to identify a gene or genes associated with the clinical form of the disease...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. BF allotypes Association Multiple sclerosis Hum Hered 1991;41:397^»02 © 1 9 9 1 S. K arger A O , Basel 1X101-5652/91/0416-0397 $ 2.75 0 Factor B (BF) Allotypes and Multiple...

...R.J. Mitchell; C.J. Eslick Blood samples from over 2,200 blood donors resident in the State of Victoria were investigated for the association between the ABO and haptoglobin (HP) blood systems reported by others. No association between the phenotypes of the 2 systems was found but the distribution...

...R.J. Mitchell; C.J. Eslick No association between the glyoxalase 1 (GLO1) and haptoglobin (HP) systems was found in a sample of 1,270 white blood donors in the State of Victoria, Australia. This finding is in contrast to previous data for blood donors in Newfoundland, Canada, a population also...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Acute appendicitis Rh (E) frequency Association Hum. Hered. 37: 384...

...V. Pausch; M. Weirather; E. Dub; J. Göbel; W.R. Mayr In contrast to the data published by Payne and Huntsman in 1982, no association between GLO I and Hp phenotypes could be found in a sample of 973 unrelated Austrians. 2 9 2008 © 1985 S. Karger AG, Basel 1985 Copyright / Drug Dosage...

...K. Virtaranta-Knowles; H.R. Nevanlinna In a sample of 903 Finns no association between Hp and GLOI phenotypes could be detected. Association Glyoxalase I Haptoglobin © 1987 S. Karger AG, Basel 1987 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part...