The exact conditional approach is frequently used for testing Hardy-Weinberg equilibrium in population genetics. This approach respects the test size as compared to the traditionally used asymptotic approaches. It is a full-enumeration method and very computational. Many efficient algorithms have been successfully developed to implement this exact approach. An alternative to the conditional approach is the unconditional approach, which relaxes the restriction of the fixed number of allelic counts as in the conditional approach. The first unconditional test considered in this study is the one based on maximization, which has been shown to be more powerful than the conditional test to loci with two alleles for small sample sizes. By using the p value of the conditional approach as a test statistic in the following maximization step, the second unconditional test is uniformly more powerful than the conditional approach. We compared these exact tests based on three commonly used test statistics with regards to type I error rate and power. It is recommended to use the second unconditional approach in practice due to the power gain in the case with two alleles.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.