Previously, it has been shown for affected sib pairs that the mean test is the uniformly (in Θ) most powerful test in case of a multiplicative mode of inheritance and that the mean test is equivalent to parametric linkage analysis calculated under an assumed multiplicative mode of inheritance. Here, these two results are extended to samples consisting of affected sib triplets. For affected sib quadruplets, however, it is shown that these results are no longer valid.

Keywords:
Linkage analysis, Mean test, Affected sib triplets, Lod score analysis
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© 2005 S. Karger AG, Basel
2005
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