The distribution of two common Taq Irestriction fragment length polymorphisms (RFLPs) of the cholesteryl ester transfer protein (CETP) gene were determined in 271 Italian-born and 170 Greek-born migrants to Melbourne, Australia. A much smaller number were examined for the Eco Nl RFLP of the same gene. Allele frequencies of the Taq lA RFLP exhibited the least variation in both ethnic groups, and no significant regional heterogeneity in allele or genotype frequencies of either Taq lRFLP was detected for Greece or Italy. There was no difference between Italians and Greeks for the Taq l A polymorphism and the variability at the B RFLP was of borderline significance. Comparisons with other Caucasian populations revealed that allele frequencies of all three CETP RFLPs are remarkably uniform within Caucasians, with the Taq lB polymorphism being the most variable.

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