A large inbred Italian kindred with 10 members homozygous for the rare Rh gene complex –D–is described. The propositus has immune antibody to a high-incidence Rh antigen: her baby required exchange transfusion. None of the other 9–D–/–D– individuals has made antibody even though 2 were women with children. This kindred supports previous observations of the excess of consanguinity among the parents of –D–homozygotes. 40.9% (instead of the 25% expected) of the offspring of –D– heterozygous parents are –D–homozygotes.