Recently, a significant sex distortion of the esterase D locus segregation, both in Portugal and Germany, was reported. In contrast to these puzzling results, data on around 1,200 informative northeastern Brazilian individuals did not show any signs of a sex-phenotype association (χ2 = 0.35). The joint analysis of this sample together with that of the previous report showed that, although the pooled material presented a significant sex distortion (p < 0.05), the heterogeneity was also high (p < 0.05) as to discourage any generalization based upon the European findings. Moreover, since the present sample is almost 3 times larger than the pooled European one, the whole picture suggests strongly that there is no segregation distortion attributed to sex, at this locus.

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