Electrophoretic variants of the red cell enzymes acid phosphatase, phosphoglucomutase, adenosine deaminase, and adenylate kinase were studied in newborn twins and their parents. In the parents, the gene frequencies were similar to the gene frequencies in the general population and the segregation of phenotypes was found to be in accordance with a Mendelian inheritance except in the acid phosphatase system where deviations were found in the segregation of dizygotic twins from BA × CB and CB × CB matings. All the monozygotic tv/ins were concordant, and the proportion of discordant phenotypes in dizygotic twins was similar to the proportion expected in sib-pairs.

Keywords:
Red cell acid phosphatase, PGM1, ADA, AK, Twin and family study
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© 1974 S. Karger AG, Basel
1974
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