An original article is generally considered a cornerstone of modern research. It is a detailed written presentation of novel and original data that undergo peer review. The current paper describes in detail how to draw up an original article effectively, using strategies such as modern information technology and a rational sequence of writing title page, materials and methods, figures and tables, legends, results, introduction, discussion, acknowledgements, abstract (summary), key words and reference list. As a preliminary step, important basic facts on medical writing are described, in particular the distinction between generating/collecting data and actually putting fingers to the keyboard. The Vancouver requirements and important aspects of authorship are discussed; how to choose a journal is also outlined. Finally we describe the repeated process of writing, reviewing and revising your manuscript together with your mentor or co-workers to obtain the highest level of quality before submission.