...Xuan Lv; Fang Li Objective: The aim of this study was to explore the mechanism of methyltransferase-like 14 (METTL14) on human endometriotic stromal cell (ESC; HEM15A) proliferation, migration, and invasion to provide novel therapy for endometriosis (EMs). Design: Normal human endometrial stromal...

... circ_0043314 regulated ovarian granulosa cell proliferation and apoptosis in PCOS via miR-146b-3p/Apelin 13 axis. Participants/Materials, Methods: Ovarian tissues (cortical tissues) from 35 PCOS patients and 35 normal controls, as well as HEK293T and human ovarian granulosa cell line (KGN, COV434), were...

... containing t-complex polypeptide 1 subunit 6A (CCT6A) and cell proliferation as well as hypoxic glycolysis. Design: Bioinformatics analysis was conducted to explore the association between cervical cancer and its partner protein under hypoxic conditions, namely, CCT6A. Subsequently, the expression of CCT6A...

...Yujing Wang; Jing Wang; Chunmei Liu; Min Li Objective: Silent information regulator 1 (SIRT1), an NAD + -dependent III class histone deacetylase, plays crucial roles in cell proliferation, apoptosis, senescence, metabolism, and stress responses. Nevertheless, the role of SIRT1 in tumorigenesis...

...-5p Migration Invasion Proliferation Prognosis Cervical cancer is a malignant tumor with a high incidence among women globally and is the main leading cause of cancer-related death to women, which is only inferior to breast cancer [1]. The majority of the new cases and deaths of cervical...

.... The proliferation, migration, invasion, and apoptosis activities of HTR8/SVneo cells were, respectively, determined by cytometry assay, scratch test, transwell assay, and FITC/PI staining. The expression levels of P53, RhoA, Bcl-2, Bax, and MMP-9 in HTR8/SVneo cells, as well as the expression levels of MNSFβ...

..., and whether TSA and caffeic acid phenyl ester can suppress constitutive and H 2 O 2 -stimulated proliferation of endometriotic cells. Methods: Two endometriotic cell lines and an endometrial stromal cell line were used as an in vitro model. Electrophoretic mobility shift analysis was used to determine NF-ĸB...

...Yan Wu; Anna Starzinski-Powitz; Sun-Wei Guo Treatment of immortalized stromal-like and epithelial-like endometriotic cells with capsaicin resulted in inhibition of proliferation in a concentration-dependent manner. In addition, endometriotic cells are more sensitive to capsaicin treatment than...

...Yan Wu; Sun-Wei Guo Background: All current major medications in treating endometriosis are effective in treating pain, most likely through suppression of proliferation of the implants, yet their effectiveness is relatively short term and they all have many undesirable, and sometimes severe, side...

...-ĸB. NF-ĸB proteins themselves and proteins regulated by them have been linked to cellular transformation, proliferation, apoptosis, angiogenesis, and invasion. Interestingly, all existing and nearly all investigational medications for endometriosis appear to act through suppression of NF-ĸB...

... a stimulatory effect of tibolone on tumor growth. Breast cancer Hormone replacement therapy Tibolone Estrogens Progestin Sulfatase Sulfotransferase Proliferation Nude mice Xenograft 25 01 2006 31 05 2006 7 8 2006 © 2007 S. Karger AG, Basel 2006 Copyright / Drug Dosage...