...Yunqin Chen; Dongguo Wang; Meiqian Zhou; Xiangjuan Chen; Jiayu Chen Background/Aims: The endothelial nitric oxide synthase (eNOS) gene has been enlisted by previous research as a candidate gene of preeclampsia predisposition. This study investigates the specific roles of 3 polymorphisms of the eNOS...

...Ahmet Karatas; Recep Eroz; Anzel Bahadır; Fatih Keskin; Tulay Ozlu; Mehmet Emin Ozyalvaclı Background/Aims: Recent investigations in both males and females show that there may also be some genetic risk factors associated with infertility, and endothelial nitric oxide synthase (eNOS) has important...

..., instructions or products referred to in the content or advertisements. Vascular endothelial growth factor Angiogenesis Nitric oxide Vasodilation Hypertension Preeclampsia Preeclampsia is a pregnancy complication characterized by hypertension and proteinuria. This syndrome has a major life...

... significantly the 5-HT-induced response, but INDO reduced this response. These results suggest that basal release of nitric oxide but not of vasodilator prostanoids may contribute to the low resting vascular tone in the NG and attenuates the strong vasoconstrictor effect induced by 5-HT. Impairment of action...

...Toshikatsu Nobunaga; Yoshihiro Tokugaw; Kazumasa Hashimoto; Tadashi Kimura; Noboru Matsuzaki; Yutaka Nitta; Tomio Fujita; Kin-ichi Kidoguchi; Chihiro Azuma; Fumitaka Saji Nitric oxide (NO) production may be an important causal factor in hypertensive disorders during pregnancy. The plasma...

...Carmen Gloria Acevedo; Ana Maria Huambachano; Ivan Bravo; Enrique Contreras The purpose of this study was to clarify the role of endogenous nitric oxide and prostanoids in ethanol-induced perturbation of microcirculation in perfused human placenta. Infusion of ethanol into chorionic plate vessels...

...Haruki Nishizawa; Kanako Pryor-Koishi; Machiko Suzuki; Takema Kato; Takao Sekiya; Shin Tada; Hiroki Kurahashi; Yasuhiro Udagawa Background: Defective nitric oxide (NO)-mediated vasodilation is widely regarded as an underlying cause of hypertension in pre-eclampsia, although there are also arguments...

... damage. In this study, we have aimed to measure homocysteine (Hcy) and nitric oxide (NO) levels as endothelial dysfunction markers in preeclamptic women. Nineteen preeclamptic (33.9 ± 1.4 weeks) and 15 gestational-age-matched normal pregnant women (35.5 ± 0.7 weeks) were included in the study. Mean...

...Michael F.E. Diejomaoh; Alexander E. Omu; Sami Taher; Nasser Al-Busiri; Tunde Fatinikun; Sanjit Fernandes; Saed Al-Othman Background: Nitric oxide has potent relaxant effects on the pregnant uterus and has been associated with a quiescent uterus in animal and human studies. Nitric oxide donors have...

...Byung Chul Jee; Seok Hyun Kim; Shin Yong Moon This study was designed to investigate the role of nitric oxide (NO) on the apoptosis of human luteinized granulosa cells and its possible pathways. Granulosa cell suspensions were incubated for 48 h after adding NO donor (S-nitroso-N-acetyl...

...Agnieszka Tomaszewska; Ibeth Guevara; Tadeusz Wilczok; Aldona Dembinska-Kiec The present study investigated the effect of 17β-estradiol (17βE 2 ) and lipopolysaccharide (LPS) on the release and expression of nitric oxide (NO), tumor necrosis factor-α (TNF-α) and vascular endothelial growth factor...

...Toshihiro Yoshimura; Ferdous Ara Chowdhury; Michihiro Yoshimura; Hitoshi Okamura Objective: We recently identified a missense variant (Glu298Asp) within exon 7 of the endothelial nitric oxide synthase (eNOS) gene that is associated with severe preeclampsia in the Japanese population. Our objective...

...Süleyman Engin Akhan; Tülin Gürel; Recep Has; Ahmet Cem Iyibozkurt; Abdullah Turfanda Objectives: The aim of this study is to evaluate the relationship between plasma nitric oxide (NO) and β-endorphin levels in women using hormone replacement therapy (HRT) for 12 months. Material and Methods: Our...

... glutathione (GSH) and nitric oxide (NO) levels in women receiving hormone replacement therapy (HRT). Materials and Methods: To examine the influence of oxidative stress on OPD, we studied 12 postmenopausal women who had received HRT for 6 months, and 13 postmenopausal women who did not receive HRT...

... were in labor. Serum nitric oxide levels were measured as total nitrites after reduction of nitrates to nitrites. Among the control subjects, nitric oxide levels were significantly lower in the cases in labor when compared to those not in labor (p < 0.05), but glutathione levels were...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Isosorbide dinitrate Nitric oxide Preeclampsia Original Paper Gynecol Obstet Invest 2000;50:39 42 Received: August 27, 1999 Accepted after revision: January 27, 2000...

... by nitric oxide was evaluated at the single cell level using the patch-clamp technique. The open probability of the K + channel after the addition of 3 × 10 –3 M isosorbide dinitrate, a nitric oxide donor (0.116 ± 0.048) was significantly higher than that before the addition (0.059 ± 0.032; n = 9, p...

... oxide synthase inhibitor, at a dose insufficient to produce hypertension, increases the pressor response to angiotensin II. 17 2 2000 Nitric oxide N G -Monomethyl- L -arginine Angiotensin II L -Arginine Blood pressure, rat © 2000 S. Karger AG, Basel 2000 Copyright / Drug Dosage...

...Ü. Mutlu-Türkoglu; G. Aykaç-Toker; L. Ibrahimoglu; E. Ademoglu; M. Uysal It has been suggested that oxidative stress may cause endothelial dysfunction and that endothelial dysfunction may lead to hypertension by reduced release of vasodilating agents such as nitric oxide (NO). In this study, we...

...Hirotaka Ota; Shinichi Igarashi; Junichi Hatazawa; Toshinobu Tanaka Recent studies have shown that synthase for nitric oxide or scavenger enzymes is distributed throughout the endometrium. We have reported that endothelial nitric oxide synthase, originally identified in vascular endothelial cells...