... with transvaginal US-guided drainage and rIL-2 left in the cysts, without using endometrial suppressive therapy with GnRH analogues as done in previous studies, has low efficacy. Recurrences are even more frequent after the use of two rIL-2 doses. Endometriomas Drainage GnRH analogues Immunomodulators...

...Yutaka Osuga It has previously been considered that the therapeutic effects of gonadotropin-releasing hormone (GnRH) analogues on endometriosis could be explained by the suppression of estrogen levels due to pituitary downregulation; however, recent research on the pathogenesis of endometriosis...

...Marta Tesone; Mariela Bilotas; Rosa Inés Barañao; Gabriela Meresman It has been postulated that gonadotropin-releasing hormone (GnRH) analogues may act directly on endometrial cells and inhibit their growth and proliferation by regulation of apoptotic and angiogenic mechanisms. Eutopic endometrial...

...) after transvaginal ultrasound (US)-guided drainage of endometriomas under the effect of GnRH analogues. Methods: Prospective and randomized clinical trial (helped by a random number table) at a University Hospital. Twenty-four consecutive patients with endometriomas initially sent to us for laparotomy...

...Pedro Acién; Francisco J. Quereda; María-José Gómez-Torres; Rosa Bermejo; Mercedes Gutierrez We performed a double-blind, randomised controlled trial to evaluate the results of ultrasound-guided aspiration of endometriomas under the effect of GnRH analogues and a possible additional beneficial...

...Eric S. Surrey GnRH analogues have been demonstrated to be effective medical therapy for symptomatic endometriosis. The use of these agents has been limited to 6 months due to hypoestrogenic side effects. A variety of steroidal and nonsteroidal add-back regimens have been used in an effort...

... or on the local production of endocrine, immunological, growth and angiogenic factors. GnRH receptors as well as GnRH analogues binding to cell membranes have been detected on human breast, ovarian and endometrial cancer cells. Thus, along with an indirect effect due to hypoestrogenism, a direct effect of GnRH...