... risk of ovarian cancer observed in patients with endometriosis. This primary prevention measure saves lives and can effectively integrate targeted risk-reducing surgery. Secondary pharmacological prevention, based on a working diagnosis of early onset adenomyosis-endometriosis selectively...

...Ying Tang; Zhi-jun Jiang; Ming-bo Wen; Bin Su; Jun-rong Huang; Hang Wang; Jia Wu; Ming-tao Yang; Na Ding; Hui-quan Hu; Fan Xu; Jun Li; Qiuling Shi Objectives: The aim of the study was to identify an optimal magnetic resonance imaging (MRI)-based classification for the severity of adenomyosis...

...Hiroshi Kobayashi Background: Adenomyosis is an estrogen-dependent gynecologic condition that can cause pain symptoms, heavy menstrual bleeding, and infertility. Several treatments, including hormonal therapy, can improve patients’ quality of life through alleviating symptoms. Dienogest (DNG), a 19...

...Xiaoli Li; Shenyi Lu; Yan Jiang; Kai Xu; Jingzhi He; Zhangli Qiu; Pian Ying Objectives: The aim of our study was to explore the role of circular RNA_0061140 (circ_0061140) in adenomyosis progression and its associated mechanism. Design: We first analyzed the expression pattern of circ_0061140...

...Hiroshi Kobayashi; Sho Matsubara There is a lack of an international consensus on adenomyosis classification that is useful for clinical practice and research. This article reviews advancements in the classification of adenomyosis, and the existing limitations. We collected a literature search from...

...Hiroshi Kobayashi; Yohei Kishi; Sho Matsubara Adenomyosis is a common gynecologic disorder defined by the presence of endometrial glands and stroma within the uterine myometrium. This review focusses on: (1) current understanding of cellular and molecular mechanisms of adenomyosis-related...

.... Adenomyoma Adenomyosis Adenomyomatous polyp  Atypical polypoid adenomyoma Endomyometriosis Polypoid adenomyoma Uterus-like-mass The need for more research focusing on benign proliferative disorders affecting the genital tract, that globally may affect 50% of all women during their lifetime...

... may arise at either or both sites. Investigating disease origin enhances our understanding of pathophysiology and prognosis. Additional critical questions are whether women with adenomyosis have a higher risk of endometrial cancer; whether the invasive properties and prognosis of cancer in adenomyosis...

... and multivariate analysis were performed to assess the potential associations between pain characteristics (dysmenorrhea, pelvic pain, dyschezia, dyspareunia or dysuria) and the location of endometriosis or other disease-related characteristics (hematuria, rectal bleeding or adenomyosis). Results: Pelvic pain...

...Thierry Van den Bosch; Angelo Votino; Ann Cornelis; Lieselore Vandermeulen; Catherine Van Pachterbeke; Dominique Van Schoubroeck; Dirk Timmerman The use of in vitro three-dimensional ultrasound examination with needle stereotaxis after hysterectomy is illustrated in a case of extensive adenomyosis...

...Gun Oh Chong; Yoon Hee Lee; Dae Gy Hong; Young Lae Cho; Yoon Soon Lee Background/Aims: To determine the long-term efficacy of laparoscopic or robotic adenomyomectomy with or without gonadotropin-releasing hormone (GnRH) for the treatment of severely symptomatic adenomyosis. Methods: Between August...

... of rapamycin (p-mTOR) in ectopic and eutopic endometria of endometriosis and adenomyosis. Methods: Endometrial specimens were obtained from healthy non-menopausal women (n = 17) or patients with ovarian endometriotic cysts (n = 48) or adenomyosis (n = 30) during January 2011 to June 2012. The expressions of DJ...

... parameters of endometrial structure and activity, the first scientist to delineate peritoneal endometriosis under the name ‘adenomyoma' was Cullen. On the other hand, Rokitansky was the first to describe a form of adenomyosis (an adenomatous polyp). Early descriptions of ovarian endometrioma as ‘haematomas...

...Lei Yan; Lingling Ding; Rong Tang; Zi-Jiang Chen Aims: To study the effect of adenomyosis on in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes in infertile patients. Methods: We performed a retrospective, database-searched cohort study based on 10,268 patients undergoing...

.... Clinicians should be prepared to evaluate nongynecologic causes of pelvic pain. Adenomyosis Dysmenorrhea Interstitial cystitis Irritable bowel syndrome Vulvodynia It is troubling that self-reported abuse (as reported in the right side of table 2 ) is so high, and to a certain extent...

...Xishi Liu; Sun-Wei Guo Objectives: To investigate the expression and localization of deoxyribonucleic acid methyltransferases (DNMTs) in women with and without adenomyosis. Study Design: Ectopic and homologous eutopic endometrium from 50 women with adenomyosis and endometrium from 18 age...

...Xishi Liu; Jichan Nie; Sun-Wei Guo Background/Aims: Adenomyosis is a common condition with a poorly understood pathogenesis. Recent data suggest that it may be an epigenetic disease. This study investigated the expression and localization of class I histone deacetylases (HDACs) in women...

...Mohamed Khairy Mehasseb; Stephen Charles Bell; Laurence Brown; James Howard Pringle; Marwan Habiba Background and Aim: To study the characteristics of the inner (IM) and outer (OM) myometrium in the presence and absence of uterine adenomyosis. Methods: Case control blinded comparison carried out...

...Satoshi Kijima; Kentaro Takahashi; Manabu Kitao To investigate the histogenic and cytogenic localization of CA 125 in patients with adenomyosis, sections from 8 adenomyosis cases were expressed with monoclonal anti-CA 125 antibodies. Consequently, CA 125 proved to be present on the glandular...

.... Tissue danazol concentration Danazol injection therapy Adenomyosis Myoma Original Paper Gynecol Obstet Invest 1995;39:207-211 Tadahiro Takebayashi Yuji Fujino Naohiko Umesaki Sachio Ogita Department of Obstetrics and Gynecology, Osaka City University Medical School, Osaka, Japan Danazol Suspension...