Article PDF first page preview

First page of Are the morphokinetics of embryos obtained from HPV-positive sperm altered? A Retrospective Cohort Study

This study focuses on the potential impact of Human Papillomavirus (HPV) infection in men on assisted reproductive technology (ART) outcomes, specifically examining sperm quality, embryo morphokinetics, and pregnancy rates. Objectives: The study aims to compare the embryological morphokinetics of ART embryos derived from HPV-positive versus HPV-negative sperm, assess fertilisation rates, morphology, and pregnancy outcomes, and determine the prevalence of HPV infection in male ART patients. Design: This is a retrospective cohort study. As established by the sample size, the participants were divided into two groups: the first sperm HPV positive group of 57 cases and the second HPV negative group of 57 cases. Participants/Materials, Setting,: We calculated the sample size for evaluating sperm parameters. The estimated number of patients required for the study was 114. The sample size for the morphogenetic evaluation of embryos was equal to 210 embryos in total. The statistical analysis involved the execution of the Student t-test, the Shapiro test the Mann-Whitney. The Chi-square or Fisher tests were then used depending on the sampled data. Methods: The enrolled couples were treated with in vitro fertilization with ICSI. Results Morphokinetics showed no statistically significant difference between the two groups examined. Therefore, the speed of the various stages of embryonic growth appears substantially identical. Limitations Morphokinetics showed no statistically significant difference (table V) between the two groups examined. Therefore, the speed of the various stages of embryonic growth appears substantially identical. Conclusions Our results suggest that the disease does not worsen the results of ART and does not modify the morphokinetics of embryos; therefore, screening for sperm HPV in males of couples scheduled for ART does not appear advisable.

Journal Section:
Research Article
This content is only available via PDF.
S. Karger AG, Basel
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
2025
You do not currently have access to this content.