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BACKGROUND: We sought to conduct a systematic review and meta-analysis of randomized clinical trials to evaluate the impact of Myo-inositol on oocyte and embryo quality in women undergoing assisted reproduction. METHODS: The systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)2020 checklist. Registration number: CRD42023433328. Studies were identified by searching PubMed, Cochrane Library, Google Scholar, Scopus, Embase and ClinicalTrials databases. RESULTS: 8 randomized clinical trials (RCTs) were included for qualitative analysis reporting on 820 participants. 4 meta-analyses were performed. Numbers of retrieved oocytes in comparison of intervention and control group were higher in inositol group (mean difference (MD) = 0.41, 95% CI: 0.05–0.77, p=0.02). Meta-analysis of two studies compared numbers of oocytes among poor ovarian responder patients showed no significant difference between intervention and control group (MD=0.50, 95% CI: 0.57–1.58, p=0.36). Miscarriage rate was no statistically significant difference between the treatment and control groups (risk ratios (RR)=0.81, 95% CI: 0.20– 3.32, p=0.77). Inositol played no role in improving clinical pregnancy rates, there was no significant difference between the intervention group and the control group (RR=1.41, 95% CI: 0.88–2.25, p=0.15). CONCLUSION: Thus, we did not find any benefits of using myo-inositol on oocyte and embryo quality in women undergoing reproductive technologies. Further studies are needed to assess efficacy, safety and high compliance by female patients.

Journal Section:
Systematic Review
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S. Karger AG, Basel
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2024
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