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Objective: To explore the impacts of liraglutide on leptin promoter methylation in ovarian granulosa cells of patients with polycystic ovary syndrome and obesity. Methods: A total of 30 patients with polycystic ovary syndrome and obesity were retrospectively analyzed. According to the method of random grouping, the patients were divided into an observation group and a control group. The control group received metformin, and the observation group received the subcutaneous injection of liraglutide. The therapeutic effects of patients in the two groups were compared. Results: After therapy, the levels of glucose metabolism, lipid metabolism-related indicators, BMI, LEP, and VF of patients were less than those before therapy, and the levels in the observation group were less than the control group (p < 0.05). After therapy, the FSH, E2 and LH levels of patients in the two groups were less than those before therapy, and those in the observation one were less than the control group (p < 0.05). After therapy, the leptin promoter methylation in luteinized granulosa cells in the observation group was less than the control group (p < 0.05). The menstrual cycle establishment ratio, normal ovulation rate, and natural pregnancy ratio of the observation group was greater than the control group (p < 0.05). Conclusion: Liraglutide has a therapeutic effect on the patients with polycystic ovary syndrome and obesity by reducing the methylation of leptin promoter in luteinized granulosa cells and improving the natural pregnancy rate.

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