Introduction: Minimally invasive procedures performed in laparoscopy, such as salpingectomy for ectopic pregnancy, can be combined with a minimally invasive anesthesia. The aim of this study was to assess the feasibility and the intraoperative and postoperative outcomes of laparoscopic surgery for ectopic pregnancy under spinal anesthesia (SA) compared to general anesthesia (GA) from the point of view of the surgeon, anesthesiologist, and patient. Methods: A retrospective cohort study was performed at DAI Materno Infantile of AOU Federico II of Naples, analyzing all medical records of women who met the inclusion criteria between April 2020 and April 2023. Eighty-two women (35 under SA in group A and 47 under GA in group B) undergone elective or emergency laparoscopic salpingectomy for ectopic tubal or ovarian pregnancy were included. Results: Patients in group A reported less pain at 0 h (adjusted mean difference: −1.5; 95% CI: −2.3 to −0.7; p < 0.001) and after 6 h (adjusted mean difference: −1.1; 95% CI: −2.0 to −0.3; p = 0.01) while no statistically significant differences between the two groups at 12 and 24 h after surgery. No differences were observed among the type of analgesic and during the postoperative observation time, except for paracetamol at 0 h in group B. A faster resumption of bowel motility, patient’s mobilization, and a shorter hospital stay were observed in group A compared to group B. Also greater odds of returning faster to daily activities emerged in group A (adjusted OR: 5.39; 95% CI: 1.77–16.37). A greater number of patients in group A were satisfied with the entire procedure compared to those of group B (33 [94.3%] vs. 37 [78.7%]). The general surgeon satisfaction was always very good or excellent in group A. Finally, all surgical steps were well tolerated in group A. Conclusion: In specific settings, SA is a feasible and safe procedure for the laparoscopic treatment of ectopic pregnancy.

1.
Della Corte
L
,
Mercorio
A
,
Morra
I
,
Riemma
G
,
De Franciscis
P
,
Palumbo
M
et al
.
Spinal anesthesia versus general anesthesia in gynecological laparoscopic surgery: a systematic review and meta-analysis
.
Gynecol Obstet Invest
.
2022
;
87
:
1
11
.
2.
Kuczkowski
KM
.
A review of obstetric anesthesia in the new millennium: where we are and where is it heading
.
Curr Opin Obstet Gynecol
.
2010
;
22
(
6
):
482
6
.
3.
Riemma
G
,
Schiattarella
A
,
Cianci
S
,
La Verde
M
,
Morlando
M
,
Sisti
G
et al
.
Transversus abdominis plane block versus wound infiltration for post-cesarean section analgesia: a systematic review and meta-analysis of randomized controlled trials
.
Int J Gynaecol Obstet
.
2021
;
153
(
3
):
383
92
.
4.
Vitale
SG
,
Alonso Pacheco
L
,
Haimovich
S
,
Riemma
G
,
De Angelis
MC
,
Carugno
J
et al
.
Pain management for in-office hysteroscopy. A practical decalogue for the operator
.
J Gynecol Obstet Hum Reprod
.
2021
;
50
(
1
):
101976
.
5.
Giampaolino
P
,
Della Corte
L
,
Mercorio
A
,
Bruzzese
D
,
Coviello
A
,
Grasso
G
et al
.
Laparoscopic gynecological surgery under minimally invasive anesthesia: a prospective cohort study
.
Updates Surg
.
2022
;
74
(
5
):
1755
62
.
6.
Mullany
K
,
Minneci
M
,
Monjazeb
R
,
C Coiado
O
.
Overview of ectopic pregnancy diagnosis, management, and innovation
.
Women’s Health
.
2023
;
19
:
17455057231160349
.
7.
Della Corte
L
,
Mercorio
A
,
Palumbo
M
,
Viciglione
F
,
Cafasso
V
,
Candice
A
et al
.
Minimally invasive anesthesia for laparoscopic hysterectomy: a case series
.
Arch Gynecol Obstet
.
2022
;
306
(
6
):
2001
7
.
8.
Yang
C
,
Cai
J
,
Geng
Y
,
Gao
Y
.
Multiple-dose and double-dose versus single-dose administration of methotrexate for the treatment of ectopic pregnancy: a systematic review and meta-analysis
.
Reprod Biomed Online
.
2017
;
34
(
4
):
383
91
.
9.
Yuk
JS
,
Lee
JH
,
Park
WI
,
Ahn
HS
,
Kim
HJ
.
Systematic review and meta-analysis of single-dose and non-single-dose methotrexate protocols in the treatment of ectopic pregnancy
.
Int J Gynaecol Obstet
.
2018
;
141
(
3
):
295
303
.
10.
Xiao
C
,
Shi
Q
,
Cheng
Q
,
Xu
J
.
Non-surgical management of tubal ectopic pregnancy: a systematic review and meta-analysis
.
Medicine
.
2021
;
100
(
50
):
e27851
.
11.
Kampioni
M
,
Chmaj-Wierzchowska
K
,
Wszołek
K
,
Wilczak
M
.
Interstitial ectopic pregnancy-case reports and medical management
.
Medicina
.
2023
;
59
(
2
):
233
.
12.
Hendriks
E
,
Rosenberg
R
,
Prine
L
.
Ectopic pregnancy: diagnosis and management
.
Am Fam Physician
.
2020
;
101
(
10
):
599
606
.
13.
Committee on Practice Bulletins—Gynecology
.
ACOG practice bulletin No. 191: tubal ectopic pregnancy
.
Obstet Gynecol
.
2018
;
131
(
2
):
e65
77
.
14.
Karavani
G
,
Gutman-Ido
E
,
Herzberg
S
,
Chill
HH
,
Cohen
A
,
Dior
UP
.
Recurrent tubal ectopic pregnancy management and the risk of a third ectopic pregnancy
.
J Minim Invasive Gynecol
.
2021
;
28
(
8
):
1497
502.e1
.
15.
Mol
F
,
Van Mello
NM
,
Strandell
A
,
Strandell
K
,
Jurkovic
D
,
Ross
J
et al
.
Salpingotomy versus salpingectomy in women with tubal pregnancy (ESEP study): an open-label, multicentre, randomised controlled trial
.
Lancet
.
2014
;
383
(
9927
):
1483
9
.
16.
Vitale
SG
,
Riemma
G
,
Cianci
A
.
Unraveling the “double whammy” dilemma: do concomitant tubal infertility and previous ectopic pregnancy shrink the possibility of live birth
.
Fertil Steril
.
2020
;
113
(
5
):
934
5
.
17.
Riemma
G
,
De Franciscis
P
,
Torella
M
,
Narciso
G
,
La Verde
M
,
Morlando
M
et al
.
Reproductive and pregnancy outcomes following embryo transfer in women with previous cesarean section: a systematic review and meta-analysis
.
Acta Obstet Gynecol Scand
.
2021
;
100
(
11
):
1949
60
.
18.
Ehrenberg-Buchner
S
,
Sandadi
S
,
Moawad
NS
,
Pinkerton
JS
,
Hurd
WW
.
Ectopic pregnancy: role of laparoscopic treatment
.
Clin Obstet Gynecol
.
2009
;
52
(
3
):
372
9
.
19.
Ng
S
,
Hamontri
S
,
Chua
I
,
Chern
B
,
Siow
A
.
Laparoscopic management of 53 cases of cornual ectopic pregnancy
.
Fertil Steril
.
2009
;
92
(
2
):
448
52
.
20.
Soriano
D
,
Vicus
D
,
Mashiach
R
,
Schiff
E
,
Seidman
D
,
Goldenberg
M
.
Laparoscopic treatment of cornual pregnancy: a series of 20 consecutive cases
.
Fertil Steril
.
2008
;
90
(
3
):
839
43
.
21.
Marchand
G
,
Masoud
AT
,
Galitsky
A
,
Azadi
A
,
Ware
K
,
Vallejo
J
et al
.
Management of interstitial pregnancy in the era of laparoscopy: a meta-analysis of 855 case studies compared with traditional techniques
.
Obstet Gynecol Sci
.
2021
;
64
(
2
):
156
73
.
22.
Landström
G
,
Thorburn
J
,
Bryman
I
.
Treatment, failures and complications of ectopic pregnancy: changes over a 20 year period
.
Hum Reprod
.
1998
;
13
(
1
):
203
7
.
23.
Fernandez
H
,
Capmas
P
,
Lucot
JP
,
Resch
B
,
Panel
P
,
Bouyer
J
et al
.
Fertility after ectopic pregnancy: the DEMETER randomized trial
.
Hum Reprod
.
2013
;
28
(
5
):
1247
53
.
24.
Düz
SA
.
Fertility outcomes after medical and surgical management of tubal ectopic pregnancy
.
Acta Clin Croat
.
2022
;
60
(
3
):
347
53
.
25.
Celik
F
,
Edipoglu
IS
.
Evaluation of preoperative anxiety and fear of anesthesia using APAIS score
.
Eur J Med Res
.
2018
;
23
(
1
):
41
.
26.
Kessler
J
,
Marhofer
P
,
Hopkins
PM
,
Hollmann
MW
.
Peripheral regional anaesthesia and outcome: lessons learned from the last 10 years
.
Br J Anaesth
.
2015
;
114
(
5
):
728
45
.
27.
Imbelloni
LE
,
Fornasari
M
,
Fialho
JC
,
Sant’Anna
R
,
Cordeiro
JA
.
General anesthesia versus spinal anesthesia for laparoscopic cholecystectomy
.
Rev Bras Anestesiol
.
2010
;
60
(
3
):
217
27
.
28.
Sarli
L
,
Costi
R
,
Sansebastiano
G
,
Trivelli
M
,
Roncoroni
L
.
Prospective randomized trial of low-pressure pneumoperitoneum for reduction of shoulder-tip pain following laparoscopy
.
Br J Surg
.
2000
87
(9):
1161
5
.
29.
Jovanović
G
,
Jakovljević
DK
,
Lukić-Šarkanović
M
.
Enhanced recovery in surgical intensive care: a review
.
Front Med
.
2018
;
5
:
256
.
30.
De Wilde
RL
,
Bakkum
EA
,
Brölmann
H
,
Crowe
A
,
Koninckx
P
,
Korell
M
et al
.
Consensus recommendations on adhesions (version 2014) for the ESGE adhesions research working group (European society for gynecological endoscopy): an expert opinion
.
Arch Gynecol Obstet
.
2014
;
290
(
3
):
581
2
.
31.
Bayoumi
M
.
Effect of general anesthesia versus spinal anesthesia in cesarean section on regain of gastrointestinal motility
.
Egypt J Hosp Med
.
2017
;
68
(
3
):
1332
8
.
32.
Raimondo
D
,
Borghese
G
,
Mastronardi
M
,
Mabrouk
M
,
Salucci
P
,
Lambertini
A
et al
.
Laparoscopic surgery for benign adnexal conditions under spinal anaesthesia: towards a multidisciplinary minimally invasive approach
.
J Gynecol Obstet Hum Reprod
.
2020
;
49
(
7
):
101813
.
33.
Zirak
N
,
Keshtan
FG
,
Razavi
M
,
Hafizi
L
,
Ahangarian
N
,
Khadem
N
et al
.
Comparison of spinal and general anesthesia in gynecologic diagnostic laparoscopy
.
Perinatology
.
2018
;
19
(
1
):
15
21
.
34.
Vitale
SG
,
Gasbarro
N
,
Lagana
AS
,
Sapia
F
,
Rapisarda
AMC
,
Valenti
G
et al
.
Safe introduction of ancillary trocars in gynecological surgery: the “yellow island” anatomical landmark
.
Ann Ital Chir
.
2016
;
87
:
608
11
.
35.
Demiryas
S
,
Donmez
T
,
Erdem
VM
,
Erdem
DA
,
Hatipoglu
E
,
Ferahman
S
et al
.
Comparison of the effects of spinal epidural and general anesthesia on coagulation and fibrinolysis in laparoscopic cholecystectomy: a randomized controlled trial: VSJ Competition, 2nd place
.
Wideochir Inne Tech Maloinwazyjne
.
2017
;
12
(
3
):
330
40
.
36.
Kejriwal
AK
,
Begum
S
,
Krishan
G
,
Agrawal
R
.
Laparoscopic cholecystectomy under segmental thoracic spinal anesthesia: a feasible economical alternative
.
Anesth Essays Res
.
2017
;
11
(
3
):
781
3
.
37.
Donmez
T
,
Erdem
VM
,
Uzman
S
,
Yildirim
D
,
Avaroglu
H
,
Ferahman
S
et al
.
Laparoscopic cholecystectomy under spinal-epidural anesthesia vs. general anaesthesia: a prospective randomised study
.
Ann Surg Treat Res
.
2017
;
92
(
3
):
136
42
.
You do not currently have access to this content.