The effects of estradiol, estrone and estriol on the tonus of the isolated vascular segments of human umbilical artery were studied by a perfusion technique. Estradiol (10 µg/ml), estrone (10 µg/ml) or estriol (2 and 10 µg/ml) produce relaxation of the vascular bed which was reflected in a significant reduction in basal pressure of segments perfused at constant rate. A dose-dependent relationship was demonstrated for estriol. The time dependence and extent of relaxation were similar for all three natural estrogens.

Keywords:
Estrogens, Human umbilical artery, Perfusion method
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© 1977 S. Karger AG, Basel
1977
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