Aim: To explore the factors affecting menarcheal age by investigating two groups of women differing in age by 10-15 years in Shanghai. Methods: Data on 5,207 women were collected from January 2011 to May 2012: 2,151 women of reproductive age from the Obstetrical Department and 3,056 women in menopause from the Medical Center of the Sixth Hospital of Shanghai City. General data and data on menarcheal age and medical history were collected. The two groups were divided into subgroups from <10 to ≥20 years, i.e. 12 subgroups in total, respectively. SPSS 17.0 software was used to examine statistical differences. Results: The onset of menarcheal age of reproductive age women was 0.5 years earlier than that of menopause women (p < 0.05). In the early menarche age group (<13 years old), there were more reproductive age and high-educated women. Correlation analysis found the current body mass index in menopausal women was significantly negatively correlated with their menarcheal age (r = -0.033, p < 0.05). Conclusions: There was a downward trend in menarcheal age in women of Shanghai and its surrounding areas. Economic environment and education background were the main factors affecting menarcheal age, and menarcheal age may be considered as a predictor of adult obesity.

1.
van Lenthe FJ, Kemper CG, van Mechelen W: Rapid maturation in adolescence results in greater obesity in adulthood: the Amsterdam Growth and Health Study. Am J Clin Nutr 1996;64:18-24.
2.
Nnoaham KE, Webster P, Kumbang J, Kennedy SH, Zondervan KT: Is early age at menarche a risk factor for endometriosis? A systematic review and meta-analysis of case-control studies. Fertil Steril 2012;98:702.e6-712.e6.
3.
Dreyfus JG, Lutsey PL, Huxley R, Pankow JS, Selvin E, Fernandez-Rhodes L, Franceschini N, Demerath EW: Age at menarche and risk of type 2 diabetes among African-American and white women in the Atherosclerosis Risk in Communities (ARIC) study. Diabetologia 2012;55:2371-2380.
4.
McPherson CP, Sellers TA, Potter JD, Bostick RM, Folsom AR: Reproductive factors and risk of endometrial cancer. The Iowa Women's Health Study. Am J Epidemiol 1996;143:1195-1202.
5.
Grings AO, Lora V, Ferreira GD, Brum IS, Corleta H, Capp E: Protein expression of estrogen receptors alpha and beta and aromatase in myometrium and uterine leiomyoma. Gynecol Obstet Invest 2012;73:113-117.
6.
Braithwaite D, Moore DH, Lustig RH, Epel ES, Ong KK, Rehkopf DH, Wang MC, Miller SM, Hiatt RA: Socioeconomic status in relation to early menarche among black and white girls. Cancer Causes Control 2009;20:713-720.
7.
Marshall LM, Spiegelman D, Goldman MB, Manson JE, Colditz GA, Barbieri RL, Stampfer MJ, Hunter DJ: A prospective study of reproductive factors and oral contraceptive use in relation to the risk of uterine leiomyomata. Fertil Steril 1998;70:432-439.
8.
D'Hooghe MB, D'Hooghe T, De Keyser J: Female gender and reproductive factors affecting risk, relapses and progression in multiple sclerosis. Gynecol Obstet Invest 2013;75:73-84.
9.
Somigliana E, Vigano P, Abbiati A, Paffoni A, Benaglia L, Vercellini P, Fedele L: Perinatal environment and endometriosis. Gynecol Obstet Invest 2011;72:135-140.
10.
Sioka C, Fotopoulos A, Georgiou A, Xourgia X, Papadopoulos A, Kalef-Ezra JA: Age at menarche, age at menopause and duration of fertility as risk factors for osteoporosis. Climacteric 2010;13:63-71.
11.
Wu XH, Liu XX, Xie KH, Wang RM, Wu YX, Liu YG: Prevalence and related factors of urinary incontinence among Hebei women of China. Gynecol Obstet Invest 2011;71:262-267.
12.
Elks CE, Perry JR, Sulem P, Chasman DI, Franceschini N, He C, Lunetta KL, Visser JA, Byrne EM, Cousminer DL, Gudbjartsson DF, Esko T, Feenstra B, Hottenga JJ, Koller DL, Kutalik Z, Lin P, Mangino M, Marongiu M, McArdle PF, Smith AV, Stolk L, van Wingerden SH, Zhao JH, Albrecht E, Corre T, Ingelsson E, Hayward C, Magnusson PK, Smith EN, Ulivi S, Warrington NM, Zgaga L, Alavere H, Amin N, Aspelund T, Bandinelli S, Barroso I, Berenson GS, Bergmann S, Blackburn H, Boerwinkle E, Buring JE, Busonero F, Campbell H, Chanock SJ, Chen W, Cornelis MC, Couper D, Coviello AD, d'Adamo P, de Faire U, de Geus EJ, Deloukas P, Doring A, Smith GD, Easton DF, Eiriksdottir G, Emilsson V, Eriksson J, Ferrucci L, Folsom AR, Foroud T, Garcia M, Gasparini P, Geller F, Gieger C, Gudnason V, Hall P, Hankinson SE, Ferreli L, Heath AC, Hernandez DG, Hofman A, Hu FB, Illig T, Jarvelin MR, Johnson AD, Karasik D, Khaw KT, Kiel DP, Kilpelainen TO, Kolcic I, Kraft P, Launer LJ, Laven JS, Li S, Liu J, Levy D, Martin NG, McArdle WL, Melbye M, Mooser V, Murray JC, Murray SS, Nalls MA, Navarro P, Nelis M, Ness AR, Northstone K, Oostra BA, Peacock M, Palmer LJ, Palotie A, Pare G, Parker AN, Pedersen NL, Peltonen L, Pennell CE, Pharoah P, Polasek O, Plump AS, Pouta A, Porcu E, Rafnar T, Rice JP, Ring SM, Rivadeneira F, Rudan I, Sala C, Salomaa V, Sanna S, Schlessinger D, Schork NJ, Scuteri A, Segre AV, Shuldiner AR, Soranzo N, Sovio U, Srinivasan SR, Strachan DP, Tammesoo ML, Tikkanen E, Toniolo D, Tsui K, Tryggvadottir L, Tyrer J, Uda M, van Dam RM, van Meurs JB, Vollenweider P, Waeber G, Wareham NJ, Waterworth DM, Weedon MN, Wichmann HE, Willemsen G, Wilson JF, Wright AF, Young L, Zhai G, Zhuang WV, Bierut LJ, Boomsma DI, Boyd HA, Crisponi L, Demerath EW, van Duijn CM, Econs MJ, Harris TB, Hunter DJ, Loos RJ, Metspalu A, Montgomery GW, Ridker PM, Spector TD, Streeten EA, Stefansson K, Thorsteinsdottir U, Uitterlinden AG, Widen E, Murabito JM, Ong KK, Murray A: Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet 2010;42:1077-1085.
13.
Chumlea WC, Schubert CM, Roche AF, Kulin HE, Lee PA, Himes JH, Sun SS: Age at menarche and racial comparisons in US girls. Pediatrics 2003;111:110-113.
14.
Thomas F, Renaud F, Benefice E, de Meeus T, Guegan JF: International variability of ages at menarche and menopause: patterns and main determinants. Hum Biol 2001;73:271-290.
15.
Anderson SE, Dallal GE, Must A: Relative weight and race influence average age at menarche: results from two nationally representative surveys of US girls studied 25 years apart. Pediatrics 2003;111:844-850.
16.
Anderson SE, Must A: Interpreting the continued decline in the average age at menarche: results from two nationally representative surveys of U.S. girls studied 10 years apart. J Pediatr 2005;147:753-760.
17.
Biro FM, Huang B, Crawford PB, Lucky AW, Striegel-Moore R, Barton BA, Daniels S: Pubertal correlates in black and white girls. J Pediatr 2006;148:234-240.
18.
Hwang JY, Shin C, Frongillo EA, Shin KR, Jo I: Secular trend in age at menarche for South Korean women born between 1920 and 1986: the Ansan Study. Ann Hum Biol 2003;30:434-442.
19.
Hosny LA, El-Ruby MO, Zaki ME, Aglan MS, Zaki MS, El Gammal MA, Mazen IM: Assessment of pubertal development in Egyptian girls. J Pediatr Endocrinol Metab 2005;18:577-584.
20.
Deng F, Tao FB, Wan YH, Hao JH, Su PY, Cao YX: Early menarche and psychopathological symptoms in young Chinese women. J Womens Health (Larchmt) 2011;20:207-213.
21.
Joinson C, Heron J, Lewis G, Croudace T, Araya R: Timing of menarche and depressive symptoms in adolescent girls from a UK cohort. Br J Psychiatry 2011;198:17-23, suppl 1-2.
22.
Chen CM: Nutrition status of the Chinese people. Biomed Environ Sci 1996;9:81-92.
23.
Hesketh T, Ding QJ, Tomkins A: Growth status and menarche in urban and rural China. Ann Hum Biol 2002;29:348-352.
24.
Ong KK, Ahmed ML, Dunger DB: Lessons from large population studies on timing and tempo of puberty (secular trends and relation to body size): the European trend. Mol Cell Endocrinol 2006;254-255:8-12.
25.
Hermanussen M, Lehmann A, Scheffler C: Psychosocial pressure and menarche: a review of historic evidence for social amenorrhea. Obstet Gynecol Surv 2012;67:237-241.
26.
Mao SH, Li HB, Jiang J, Sun X, Cheng JC, Qiu Y: An updated analysis of pubertal linear growth characteristics and age at menarche in ethnic Chinese. Am J Hum Biol 2011;23:132-137.
27.
Anderson CA, Duffy DL, Martin NG, Visscher PM: Estimation of variance components for age at menarche in twin families. Behav Genet 2007;37:668-677.
28.
Cheng G, Buyken AE, Shi L, Karaolis-Danckert N, Kroke A, Wudy SA, Degen GH, Remer T: Beyond overweight: nutrition as an important lifestyle factor influencing timing of puberty. Nutr Rev 2012;70:133-152.
29.
Freedman DS, Khan LK, Serdula MK, Dietz WH, Srinivasan SR, Berenson GS: Relation of age at menarche to race, time period, and anthropometric dimensions: the Bogalusa Heart Study. Pediatrics 2002;110:e43.
30.
dos Santos Silva I, De Stavola BL, Mann V, Kuh D, Hardy R, Wadsworth ME: Prenatal factors, childhood growth trajectories and age at menarche. Int J Epidemiol 2002;31:405-412.
31.
Sloboda DM, Hart R, Doherty DA, Pennell CE, Hickey M: Age at menarche: influences of prenatal and postnatal growth. J Clin Endocrinol Metab 2007;92:46-50.
32.
Lassek WD, Gaulin SJ: Brief communication: menarche is related to fat distribution. Am J Phys Anthropol 2007;133:1147-1151.
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