Background: To determine the impact of caffeic acid phenethyl ester (CAPE) on abdominal adhesion formation after laparotomy. Methods: Forty female rats were allocated into four distinct groups on which laparotomy alone; laparotomy with traumatization of the uterine horns; laparotomy, traumatization of the uterine horns and intraperitoneal irrigation with saline, and laparotomy, traumatization of the uterine horns and intraperitoneal irrigation with CAPE were performed. After sacrifying the animals on the 14th postoperative day, histopathological examination and biochemical analysis were conducted to evaluate the formation of abdominal adhesions and antioxidant status. Results: In the CAPE group, total adhesion scores were significantly lower than in the control and saline groups. The CAPE group displayed less inflammation, giant cell formation, fibrosis and fibroblastic activity than the control group. On the other hand, the control group displayed higher total adhesion scores. Conclusion: The results of this study indicate that the administration of CAPE may have beneficial effects for the prevention of abdominal adhesion formation after laparotomy. Further clinical studies are mandatory to explore the actual therapeutic potential of CAPE.

Keywords:
Caffeic acid phenethyl ester, Laparotomy, Adhesion formation
1.
Hsu WC, Chang WC, Huang SC, Torng PL, Chang DY, Sheu BC: Visceral sliding technique is useful for detecting abdominal adhesion and preventing laparoscopic surgical complications. Gynecol Obstet Invest 2006;62:75-78.
2.
Cetin M, Duran B, Demirkoprulu N, Guvenal T, Erden O, Cetin A: Effects of diazeniumdiolates (NONOates) and methylene blue on the reduction of postoperative adhesion in rats. Gynecol Obstet Invest 2004;57:186-190.
3.
Hatipoğlu A, Türkyilmaz Z, Mert S: The effects of melatonin on postoperative intraabdominal adhesion formation. Yonsei Med J 2007;48:659-664.
4.
Leach RE, Burns JW, Dawe EJ, Smith Barbour MD: Diamond MP: Reduction of postsurgical adhesion formation in the rabbit uterine horn model with use of hyaluronate/carboxymethylcellulose gel. Fertil Steril 1998;69:415-418.
5.
Tayman C, Tonbul A, Kosus A, Hirfanoglu IM, Haltas H, Uysal S, Tatli MM, Andiran F: Protective effects of caffeic acid phenethyl ester (CAPE) on intestinal damage in necrotizing enterocolitis. Pediatr Surg Int 2011;27:1179-1189.
6.
Iraz M, Ozerol E, Gulec M, Tasdemir S, Idiz N, Fadillioglu E, Naziroglu M, Akyol O: Protective effect of caffeic acid phenethyl ester (CAPE) administration on cisplatin-induced oxidative damage to liver in rat. Cell Biochem Funct 2006;24:357-361.
7.
Ozyurt H, Söğüt S, Yildirim Z, Kart L, Iraz M, Armutçu F, Temel I, Ozen S, Uzun A, Akyol O: Inhibitory effect of caffeic acid phenethyl ester on bleomycine-induced lung fibrosis in rats. Clin Chim Acta 2004;339:65-75.
8.
Wu Y, Starzinski-Powitz A, Guo SW: Constitutive and tumor necrosis factor-alpha-stimulated activation of nuclear factor-kappaB in immortalized endometriotic cells and their suppression by trichostatin A. Gynecol Obstet Invest 2010;70:23-33.
9.
Ozyurt B, Iraz M, Koca K, Ozyurt H, Sahin S: Protective effects of caffeic acid phenethyl ester on skeletal muscle ischemia-reperfusion injury in rats. Mol Cell Biochem 2006;292:197-203.
10.
Turkyilmaz S, Alhan E, Ercin C, Kural Vanizor B, Kaklikkaya N, Ates B, Erdogan S, Topaloglu S: Effects of caffeic acid phenethyl ester on pancreatitis in rats. J Surg Res 2008;145:19-24.
11.
Akyol A, Ulusoy H, Imamoğlu M, Cay A, Yuluğ E, Alver A, Ertürk E, Koşucu M, Beşir A, Akyol A, Ozen I: Does propofol or caffeic acid phenethyl ester prevent lung injury after hind limb ischaemia-reperfusion in ventilated rats. Injury 2006;37:380-387.
12.
Fadillioglu E, Oztas E, Erdogan H, Yagmurca M, Sogut S, Ucar M, Irmak MK: Protective effects of caffeic acid phenethyl ester on doxorubicin-induced cardiotoxicity in rats. J Appl Toxicol 2004;24:47-52.
13.
Eser O, Cosar M, Sahin O, Mollaoglu H, Sezer M, Yaman M, Songur A: The neuroprotective effects of caffeic acid phenethyl ester (CAPE) in the hippocampal formation of cigarette smoke exposed rabbits. Pathology 2007;39:433-437.
14.
Mollaoglu H, Gokcimen A, Ozguner F, Oktem F, Koyu A, Kocak A, Demirin H, Gokalp O, Cicek E: Caffeic acid phenethyl ester prevents cadmium-induced cardiac impairment in rat. Toxicology 2006;227:15-20.
15.
Erel O: A novel automated direct measurement method for total antioxidant capacity using a new generation more stable ABTS radical cation. Clin Biochem 2004;37:277-285.
16.
Erel O: A new automated colorimetric method for measuring total oxidant status. Clin Biochem 2005;38:1103-1111.
17.
Hu ML, Louie S, Cross CE, Motchnik P, Halliwell B: Antioxidant protection against hyochlorous acid in human plasma. J Lab Clin Med 1993;121:257-262.
18.
Uzar E, Alp H, Cevik MU, Fırat U, Evliyaoglu O, Tufek A, Altun Y: Ellagic acid attenuates oxidative stress on brain and sciatic nerve and improves histopathology of brain in streptozotocin-induced diabetic rats. Neurol Sci 2012;33:567-574.
© 2013 S. Karger AG, Basel
2013
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.