Background: The objective of this study is to investigate the influence of male age on human fertility, defined as the birth rate for a given population. Methods: Data from the Spanish National Statistics Institute (INE) for the year 2004 from a total of 454,753 newborn infants and sorted by male and female age groups were evaluated. In order to correct the influence of female age-related fertility, a different analysis was performed considering only women under 30 years of age. Results: From a demographic point of view, male fertility started to decline at 35–39 years of age. This decline is constant and follows an exponential pattern (slope –0.11 to –0.12). The trend persisted when the data were adjusted for every 1,000 men in the age group, as well as when only women under the age of 30 were considered. Male fertility showed a 21–23% annual decrease starting at the age of 39. Conclusion: An exponential decrease in human fertility which is independent of the woman’s age was observed with male aging. This decay is probably due to a downfall in male fecundity, closely related to a decline in sperm quality. However, social or behavioral causes for this trend cannot be excluded.

Keywords:
Human fertility, Fertility, male age, Sperm quality, demography, Natural fertility, Birth rate
1.
Habbema JD, Collins J, Leridon H, Evers JL, Lunenfeld B, te Velde ER: Towards less confusing terminology in reproductive medicine: a proposal. Hum Reprod 2004;19:1497–1501.
2.
Frank O: The demography of fertility and infertility; in Campana A (ed): Frontiers in Endocrinology. Reproductive Health. Rome, Ares-Serono Symposia Publications, 1993, pp 81–92.
3.
Last JM: A Dictionary of Epidemiology, ed 2. New York, Oxford University Press, 1988, pp 1–141.
4.
International Union for the Scientific Study of Population (IUSSP) Multilingual Demographic Dictionary. Liege, IUSSP, 1982.
5.
Wood JW: Fecundity and natural fertility in humans. Oxf Rev Reprod Biol 1989;11:61–109.
6.
Frank O, Bongaarts J: Behavioural and biological determinants of fertility transition in sub-Saharan Africa. Stat Med 1991;10:161–175.
7.
Van Noord-Zaadstra BM, Looman CW, Alsbach H, Habbema JD, te Velde ER, Karbaat J: Delaying childbearing: effect of age on fecundity and outcome of pregnancy. BMJ 2001;302:1361–1365.
8.
Van Balen F, Verdurmen JE, Ketting E: Age, the desire to have a child and cumulative pregnancy rate. Hum Reprod 1997;12:623–627.
9.
Nybo Andersen AM, Wohlfahrt J, Christens P, Olsen J, Melbye M: Maternal age and fetal loss: population-based register linkage study. BMJ 2000;320:1708–1712.
10.
Auger J, Kunstman JM, Czyglik F, Jouannet P: Decline in semen quality among fertile men in Paris during the last 20 years. N Engl J Med 1995;332:281–285.
11.
Rolf C, Behre HM, Nieschlag E: Reproductive parameters of older compared to younger men of infertile couples. Int J Androl 1996;19:135–142.
12.
Andolz P, Bielsa MA, Vila J: Evolution of semen quality in northeastern Spain: a study in 22,759 infertile men over a 26-year period. Hum Reprod 1999;14:731–735.
13.
Kidd SA, Eskenazi B, Wyrobek AJ: Effect of male age on semen quality and fertility: a review of the literature. Fertil Steril 2001;75:237–248.
14.
Brzechffa PR, Daneshmand S, Buyalos RP: Sequential clomiphene citrate and human menopausal gonadotrophin with intrauterine insemination: the effect of patient age on clinical outcome. Hum Reprod1998;13:2110–2114.
15.
Mathieu C, Ecochard R, Bied V, Lornage J, Czyba JC: Cumulative conception rate following intrauterine artificial insemination with husband’s spermatozoa: influence of husband’s age. Hum Reprod 1995;10:1090–1097.
16.
Watanabe Y, Cornet D, Merviel P, Mandelbaum J, Antoine JM, Uzan S: Influence of husband’s age on outcome of a shared oocyte donation program. Fertil Steril 2000;74:578–579.
17.
Spandorfer SD, Avrech OM, Colombero LT, Rosenwaks Z: Effects of paternal age on fertilization and pregnancy characteristics in couples treated by intracytoplasmic sperm injection. Hum Reprod 1988;13:334–338.
18.
Gallardo E, Simon C, Levy M, Guanes PP, Remohi J, Pellicer A: Effect of age on sperm fertility potential: oocyte donation as a model. Fertil Steril 1996;66:260–264.
19.
ESHRE Capri Workshop Group: Fertility and ageing. Hum Reprod Update 2005;11:261–276.
20.
Speroff L: The effect of aging on fertility. Curr Opin Obstet Gynecol 1994;6:115–120.
21.
Joffe M, Li Z: Male and female factors in fertility. Am J Epidemiol 1994;140:921–929.
22.
De la Rochebrochard E, McElreavey K, Thonneau P: Paternal age over 40 years: The ‘amber light’ in the reproductive life of men? J Androl 2003;24:459–465.
23.
Olsen J: Subfecundity according to the age of the mother and the father. Dan Med Bull 1990;37:281–282.
24.
Ford JH, MacCormac L, Hiller J: PALS (pregnancy and lifestyle study): association between occupational and environmental exposure to chemicals and reproductive outcome. Mutat Res: 1994;313:153–164.
25.
Ford WC, North K, Taylor H, Farrow A, Hull MG, Golding J: Increasing paternal age is associated with delayed conception in a large population of fertile couples: evidence for declining fecundity in older men. The ALSPAC Study Team (Avon Longitudinal Study of Pregnancy and Childhood). Hum Reprod 2000;15:1703–1708.
26.
Dunson DB, Colombo B, Baird DD: Changes with age in the level and duration of fertility in the menstrual cycle. Hum Reprod 2002;17:1399–1403.
27.
Hassan SA, Killick MR: Effect of male age on fertility: evidence for the decline in male fertility with increasing age. Fertil Steril 2003:79:1520–1527.
28.
Kinsey AC, Pomeroy WC, Martin CE: Sexual Behaviour in the Human Male. Philadelphia, Saunders, 1948.
29.
Kühnert B, Nieschlag E: Reproductive functions of the ageing male. Hum Reprod Update 2004;10:327–339.
30.
Anderson, BA: Male age and infertility. Results from Ireland prior to 1911. Popul Index 1975;41:561–567.
31.
Mineau GP, Trussell J: A specification of marital fertility by parents’ age, age at marriage and marital duration. Demography 1982;19:335–350.
32.
Goldman N, Montgomery M: Fecundability and husband’s age. Soc Biol 1989;36:146–166.
33.
Strassmann BI, Warner JH: Predictors of fecundability and conception waits among the Dogon of Mali. Am J Phys Anthropol 1998;105:167–184.
34.
Lobo RA: Menopause and aging; in Strauss F, Barbieri RL (eds): Yen & Jaffe’s Reproductive Endocrinology, Physiology, Pathophysiology, and Clinical Management, ed 6. Philadelphia, Saunders/Elsevier, 2009, p 532.
35.
Eskenazi B, Wyrobek AJ, Sloter E, Kidd SA, Moore L, Young S, Moore D: The association of age and semen quality in healthy men. Hum Reprod 2003;18:447–454.
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