Using the Mishell and Dutton culture system an assay was developed for eliciting and quantifying sperm surface antigen (SSA)-specific immune responses in vitro. Peripheral blood mononuclear cells (PBMC) from sexually inexperienced and experienced women that were antisperm antibody (ASA) negative gave rise to a plaque-forming cell (PFC) response of similar magnitude (1,362 and 1,254 PFC/culture, respectively). PBMC from women that were ASA positive had lower PFC responses if cervical mucous antibodies were detected along with circulating antibodies (876 PFC/culture) than if they were not detected (1,512 PFC/culture). Limit dilution analysis was used to demonstrate that the level of the anticipated antibody response is regulated by T helper cell activity. The results of this investigation suggest that the antibody response to SSA is governed at least in part by both the secretory immune system and circulating T helper cells.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.