A statistically significant difference in the frequency of out-of-phase biopsies was found on comparison of day dating in two sequential series of late luteal endometrial biopsies taken with the standard 4-mm stainless steel Novak curette and a polypropylene cannula (‘Pipelle’). Since the only variable in these two series was the type of biopsy instrument used, it is suggested that the diagnosis of inadequate luteal phase can be affected by an extrinsic non-biological factor, i.e., the type of biopsy instrument used. This technical ‘artifact’ deserves further study.

Keywords:
Endometrial biopsy, Novak curette, Polypropylene cannula, Inadequate luteal phase
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© 1988 S. Karger AG, Basel
1988
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