Explants of the ventral prostate of adult rats, were maintained in organ culture with various steroids and insulin. In addition to androgens glucocorticoids and insulin were necessary for the maximal stimulation of the explants as judged by measuring the incorporation of labeled precursors into DNA, RNA and protein and the formation of 14CO2 from 1FC-glucose by explants. The addition of cyproterone, a steroid with high antiandrogenic potency to the culture medium suppressed the testosterone action, but did not interfere withthe effects of insulin. These findings were taken as a proof of the direct and specific antiandrogenic action of cyproterone on the rat prostate.

Keywords:
Androgens, Antiandrogens, Prostate, Tissue culture, Glucocorticoids, Insulin
This content is only available via PDF.
© 1971/1972 S. Karger AG, Basel
1971
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.