... a time as possible. Although longer treatment (5 days or more) may ensure lower relapse rates, as demonstrated in clinical studies, shorter treatments may be preferred when delivery is closer at hand. In the present study, a 1 -day treatment with one 240-mg suppository of terconazole provided a 85% cure...

...S. Wesel; G. Benijts; J.M.H. Ubachs; B. Dogniez This open-ended study was performed to compare the therapeutic effect and the clinical tolerability of a 5-day treatment with terconazole 0.8% cream with that of 6 days with clotrimazole 100-mg vaginal tablets. 75 patients on terconazole and 73...

...G. Grice; R.C. Spencer; C.E. Steele; G.R. Kinghorn An open randomized study in 97 women with culture-confirmed symptomatic vaginal candidosis was performed to compare the efficacy and acceptability of single-dose treatment with terconazole 240 mg vaginal suppositories to that of clotrimazole 500 mg...

...B.K. Kennedy; N. Friedmann Two studies of the absorption and excretion of terconazole were carried out in healthy women. In the first study, 38 women used terconazole cream either 0.2, 0.4, 0.8 or 2.0%, or placebo, administered vaginally daily for 7 days. Whole blood samples were taken at various...

... that a short-term treatment might be appropriate. In the present study, 59 women were given short-term treatment. All had mycotic infections demonstrated by cultures on Nickerson’s medium. 29 patients were treated with one terconazole 240-mg vaginal suppository and 30 women received two isoconazole 300-mg...

...C. Nahmanovici 3 days’ treatment of vaginal candidosis with imidazole derivatives has been shown to be effective and well tolerated. A dosage form of terconazole has been developed specifically for this treatment duration and 80 mg ovules have proved effective. We have performed a double-blind...

...E.W. Loendersloot Vulvovaginal candidosis occurs frequently in women of reproductive age. Local therapy with imidazole derivatives is very effective and should be preferred to oral therapy. In a multicentre trial in Holland and Belgium a single-dose treatment with a 240-mg terconazole vaginal...

...R.Y. Cartwright Terconazole is a triazole ketal with clinically useful antifungal activity. It is active against both Candida albicans and a range of dermatophytes. Animal and preliminary clinical studies have shown the drug to be non-toxic and virtually free from side-effects. It is a further...

...G. Martinek About 2,000 women with vulvovaginal candidosis were included in clinical, mostly multicentric studies with terconazole formulations applicable by the vaginal route. In addition to these clinical studies, more basic studies were performed between 1980 and 1982. 1,179 subjects were...

... a lower relapse rate after 6 days’ therapy. It appeared to be necessary to develop a terconazole formulation adapted for this treatment duration. Our studies comparing various dosages demonstrated that 40 mg/day was adequate for a 6-day treatment. 102 patients with biologically proved vaginal candidosis...

...H.-G. Siedentopf Two groups each of 38 women with cultures positive for Candida on Sabouraud’s medium were studied. One group was given terconazole 0.8% cream for 5 days and the other clotrimazole 1% cream for 6 days. 1 week after treatment cultures from the whole terconazole group were negative...

...M. Litschgi The present open study was performed to demonstrate the clinical effectiveness and tolerability of terconazole vaginal suppositories 240 mg. A total of 128 women (21 pregnant) with vaginal candidosis were treated with one vaginal suppository each. The mycological cure rates after 1 week...

...D.M. Isaacson; B. Foleno; E.L. Tolman; M.E. Rosenthale Terconazole, a new triazole ketal, is a broad-spectrum antifungal agent clinically effective against vaginal candidosis. Terconazole produces a larger zone of inhibition than clotrimazole and isoconazole when tested against Candida albicans...