Beim Protein 90K handelt es sich um ein von Tumorzellen produziertes Molekül, das sowohl zu einer Steigerung der zytotoxischen Aktivität von lymphokinaktivierten und natürlichen Killerzellen als auch zu einer Zunahme der IL-2-Freisetzung aus peripheren Blutlymphozyten führt. Wir haben einen stimulierenden Effekt von IFN-α und IFN-γ auf die Expression von 90K-spezifischer mRNS und Proteinfreisetzung zeigen können. Des weiteren scheint rekombinantes 90K die Zellen der monozytären Makrophagenreihe zu aktivieren. Das tumorassoziierte immunstimulierende Protein 90K könnte ein wichtiges Bindeglied zwischen Tumor und Immunsystem darstellen.

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