Zahlreiche Behandlungsmöglichkeiten der Symptome des Lichen sclerosus, mit meist geringem Erfolg, wurden bisher beschrieben. Testosteron 2% lokal galt während Jahren als Therapie der Wahl, wobei Erfolgsraten zwischen 67 und 100% berichtet wurden. Neuere mit Plazebo kontrollierte Untersuchungen zeigten Remissionsraten von lediglich 20% (Testosteron) and 10% (Plazebo). Bei lokaler Applikation von Kortikosteroiden der Klasse 4 (z.B. Clobetasol 0,05%) hingegen wurden Remissionsraten bis zu 75% beobachtet, wobei die befürchteten kortikosteroidbedingten Nebenwirkungen, wie z.B. Hautatrophie, auch bei mehrwöchiger Applikation kein Problem darstellten.

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