Beim fortgeschrittenen oder rezidivierenden Endometriumkarzinom stellen Doxorubicin, Epirubicin, Cisplatin, Carboblatin, Paclitaxel, Ifosfamid, 5-Fluorouracil und Vincristin die aktivsten Einzelsubstanzen dar mit Ansprechraten zwischen 18 und 36%. Die vorliegenden Daten weisen darauf hin, dass bei gegebener Indikation einer Chemotherapie die Kombinationschemotherapie mit Doxorubicin und Cisplatin die Standardchemotherapie beim fortgeschrittenen oder rezidivierenden Endometriumkarzinom mit Ansprechraten von 47–60% darstellt. Eine erste Studie mit Paclitaxel in Kombination mit diesen Substanzen zeigte eine Erhöhung der Ansprechrate auf 73%, bezüglich Überlebensvorteil liegen jedoch noch keine Daten vor. Die Kombination der Chemotherapie mit einer Gestagentherapie scheint keinen additiven Effekt zu zeigen. In der adjuvanten Situation zeigte weder die Chemotherapie noch die Hormontherapie einen Vorteil beim frühen Endometriumkarzinom.

Keywords:
Endometriumkarzinom, Chemotherapie, Uterus, Karzinom
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1999
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