Fragestellung: In der vorliegenden Arbeit wurde versucht, die in der Dezidua der Frühschwangerschaft dominierenden large granular lymphocytes (LGL) näher zu charakterisieren, um so einen Einblick in die funktionelle Bedeutung dieser Zellen im Rahmen der Plazentation zu gewinnen. Methoden: Die LGL wurden mit Hilfe von immunhistochemischen, druchfluβzytometrischen und molekularbiologischen Methoden untersucht. Ergebnisse mit Schluβfolgerungen: Die LGL ähneln einer kleinen Subpopulation von NK-Zellen aus dem peripheren Blut, exprimieren Aktivierungsantigene und bilden Zytokine, die einen egulativmodulierenden Einfluβ auf das Trophoblastenwachstum ausüben können.

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