Fragestellung: 1st die Folsäuresupplementierung zur Prävention von Neuralrohrdefekten effektiv? Wie könnte eine Empfehlung zur perikonzeptionellen Folsäuresupplementierung in Deutschland praktisch umgesetzt werden? Methoden: Analyse der verfügbaren Literatur und medizinischer Versorgungsmöglichkeiten in Deutschland. Ergebnisse: Die verfügbaren Daten lassen annehmen, dass die Rate der Neuralrohrdefekte durch die perikonzeptionelle Folsäure reduziert werden kann. Praktische Probleme der Implementation einer solchen Präventionsmassnahme bestehen jedoch hinsichtlich der Aufklärung der Zielgruppe, der Verbreitung der Vitamineinnahme in der Zielgruppe und der Verfügbarkeit geeigneter Präparate. Schlussfolgerungen: Verschiedene Fachgesellschaften empfehlen zur Reduktion des Wiederholungsrisikos die Gabe von 4 mg Folsäure bei Kinderwunsch, für Frauen ohne besonderes Risiko die Gabe von 0.4 mg/Tag

Keywords:
Neural tube defects, Folic acid, Prevention strategies
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© 1995 S. Karger AG, Basel
1995
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