Lippman und Mitarbeiter berichteten vor kurzer Zeit über eine hohe Ansprechrate von Patientinnen mit einem Zervixkarzinom unter der Therapie mit Interferon-α und 13-cis- Vitamin-A-Säure. Wir beobachteten in vitro bei Mammakarzinomzellen eine synergistische antiproliferative Wirkung von Interferon und Vitamin-A-Säure. Der Mechanismus dieser synergistischen Interaktion wurde bis dato noch nicht aufgeklärt. Erste Untersuchungen ergaben, dass Interferon einerseits die Expression eines Rezeptors für Vitamin-A-Säure steigert, andererseits ein zytoplasmatisches Bindungsprotein für Vitamin-A-Säure unterdrückt wird.

Keywords:
Retinoic acid, Interferon, Synergism
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© 1994 S. Karger AG, Basel
1994
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