Die Dosis-Wirkungs-Beziehungen der Zytostatika Taxol und Cisplatin und deren Kombination werden an einer bekannten Ovarialkarzinomzellinie (BG-1) aufgezeigt. DafÜr wurden einerseits die ChemosensibilitÄtsprofile der einzelnen Zytostatika bzw. deren Kombination in 5 verschiedenen Konzentrationen und andererseits die Zytomorphologie untersucht. Zur Bestimmung der ChemosensibilitÄtsprofile wurde der ATP-ChemosensibilitÄtsassay (ATP-CSA) verwendet. Unsere Untersuchungen zeigten, dass der ATP-CSA effektiv in der Lage ist, die Fraktion der Überlebenden Zellen zu quantifizieren und dieser ein reproduzierbares Messinstrument fÜr die ZytotoxizitÄt darstellt. Es war mÖglich, gleichzeitig die zytomorphologische Zytostatikawirkung zu analysieren. Die Bedeutung der Ergebnisse fÜr die gynÄkologisch-onkologische Praxis wird erlÄutert.

Keywords:
Taxol, Cisplatinum, ATP cell viability assay, Cytology
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© 1994 S. Karger AG, Basel
1994
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