Pregnancy is a well-known predisposing factor for vaginal candidosis. Relapses are frequent, even after successful treatment, and the therapeutic approach must aim at safety for the mother and her unborn child as well as maximum comfort for the patient, since she is more likely to suffer repeated attacks of this uncomfortable condition. Vaginal infection at delivery may entail contamination of the newborn and, although mostly benign, this condition may be associated with feeding problems and chronic skin irritation. It is thus important to have an efficient therapy for as short a time as possible. Although longer treatment (5 days or more) may ensure lower relapse rates, as demonstrated in clinical studies, shorter treatments may be preferred when delivery is closer at hand. In the present study, a 1 -day treatment with one 240-mg suppository of terconazole provided a 85% cure rate, quite comparable with a 3-day regimen with either terconazole (3 × 80 mg) or clotrimazole (3 × 200 mg). Only 1 patient in the clotrimazole group mentioned itching and burning as a side-effect.

Keywords:
Clotrimazole, Pregnancy, Terconazole, Vulvovaginal candidosis
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© 1985 S. Karger AG, Basel
1985
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