In a controlled field study, we tested the therapeutic and prophylactic efficacy of vaccination with SolcoTrichovac against Trichomonas vaginalis. At the time of the interim evaluation presented here, a total of 152 female patients had been vaccinated and were eligible for a concluding evaluation. Some of these patients had been concurrently treated with trichomonacides, locally and/or systemically. A second group was treated locally with ointments and creams, alleviating pruritus and pain but without a trichomonacidal component of action. A third group of patients was given only the vaccination therapy. As expected, the abundance of trichomonads receded faster in those patients who had been treated concurrently with trichomonacides. However, 15 and 30 days after the start of therapy, the abundance of trichomonads in the two other groups, which had received no trichomonacides, had receded to a comparable extent. After 3 months, 91 % of all the women were free of trichomonads, and after 12 months this had increased to 95%.

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