Variations of the karyogram in aging livers depend, like those after necrotising liver lesions, on alterations of the perceeding mitoses. Two main forms are discernable: slight functional alterations of the achromatic apparatus and severe disturbances of its formation. The former manifest in impairment of telophasic cytokinesis, in anaphasic stickiness or metaphasic chromosomal aberration, respectively. Mainly they lead to double nuclei, occasionally to so-called pseudoamitoses. Alterations in spindle-formation occur in prophasis, monopolar mitosis, acentrical chromosomal scattering and mitotic collapse being the essential types. They give rise to large polyploid nuclei, possibly containing inclusions, or to irregular configurated commonly lateron confluencing karyomerites. Apart from these types mitoses of polyploid and double nucleated cells sometines develop multipolar or tripolar spindle figures, the causal genesis of which is discussed. Otherwise they can result in bipolar or monopolar giant achromatic apparatus. Consequences of their restitution are karyomerites of variable sizes, uniform large polyploid nuclei or – rarely- three or four identical nuclei within one single cell. Possible causes of the respective disturbances of the achromatic apparatus and their way leading to the various nuclear types will be explained and demonstrated as general phenomenons occuring in organs other than the liver too.

Keywords:
Human liver, Karyogram, Mitosis
This content is only available via PDF.
© 1973 S. Karger AG, Basel
1973
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.