Enzyme assays in young (3–10 days), adult (6 months), middle-aged (18 months) and old (30 months) male and female C57 and C3H (6 and 12 months) mouse livers and lungs revealed complex patterns of change. Alkaline phosphatase, acid phosphatase, β-glucuronidase, G6PDH, LDH, SDH, cytochrome oxidase, glucose-6-phosphatase, 5′-nucleotidase, glycogen phosphorylase, phosphoglucomutase, ATPase and NAD dia-phorase were measured. In livers of males glycogen phosphorylase was unchanged; acid phosphatase and phosphoglucomutase increased; and glucose-6-phosphatase decreased with age. In livers of females similar patterns of change were found except that 5′-nucleo-tidase was constant; ATPase increased with age. In lungs of males glycogen phosphorylase was unchanged, alkaline phosphatase and phosphoglucomutase increased while acid phosphatase and NAD diaphorase decreased with age. In lungs of females many enzymes showed a different pattern. Acid and alkaline phosphatases, G6PDH, LDH and 5′-nucleotidase were constant and ATPase increased with age. Many enzymes showed either a high peak of activity at 18 months or a decrease in activity with age until 18 months followed by an increase. Light and electron microscope histochemistry showed no changes in enzyme localisation with age. The most common quantitative changes with age were found in the mitochondrial enzymes SDH which showed peak activity at 18 months and LDH which showed peak activity at 6 months.

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