...Fujio Takeuchi; Makoto Goto; Terumasa Miyamoto The thermostability of erythrocyte hypoxanthine guanine phosphoribosyltrans-ferase of 2 Werner’s syndrome patients was compared with that of normal subjects of different ages. No significant difference was observed regarding the thermal stability...

...Jun Nakura; Tetsuro Miki; Keiko Nagano; Koichi Kihara; Lin Ye; Kouzin Kamino; Yoshisada Fujiwara; Sho Yoshida; Shunichi Murano; Ken-ichiro Fukuchi; Ellen M. Wijsman; George M. Martin; Gerard D. Schellenberg; Toshio Ogihara Werner’s syndrome (WRN) is a rare autosomal recessive disorder characterized...

...K.V.A. Thompson; R. Holliday Fibroblast cultures were established from skin biopsies from 4 male Werner’s syndrome patients, aged 45–50. Several subcultures were obtained from each primary outgrowth and these were passaged to the end of their in vitro lifespan. Their average longevity...

...R. Holliday; K.V.A. Thompson The level of heat-labile glucose-6-phosphate dehydrogenase (G6PD) has been measured in skin fibroblast cultures from premature ageing or DNA repair deficient genetic syndromes. The short in vitro longevity of Werner’s syndrome, progeria, Cockayne’s syndrome, ataxia...

...Katsumi Murata 3 cases of Werner’s syndrome were studied on serum lipid metabolism in comparison with clinical manifestation. These 3 cases showed hyperlipemia all with hypertriglycemia and increased level of very low density lipoprotein. The lipoprotein lipase activity was shown after intravenous...

...Y. Saito Abnormal lipoprotein metabolism and its cause were studied in 10 patients with Werner’s syndrome. Seven of the 10 patients had hypercholesterolemia ( > 250 mg dI -1 ). A significant positive correlation (p < 0.01) was found between serum total cholesterol levels and LDL receptor...

...Kazuto Sato; Makoto Goto; Kusuki Nishioka; Kiminobu Arima; Natsuki Hori; Noriko Yamashita; Yoshihide Fujimoto; Hiroko Nanko; Kuniaki Ohara; Kunitoshi Ohara We present 5 cases of Werner’s syndrome associated with malignancies and a survey of 26 cases in the Japanese literature. Though tumors...

... patients with Werner’s syndrome. Upon growth inhibition in a confluent culture the net rates of increase of cellular AF were found to vary widely among the cell strains. The respective net rates of increase of AF of the cells from patients with Werner’s syndrome and the Spielmeyer-Vogt syndrome were within...

...Sudhir Gupta Peripheral blood from 4 patients with progeria and their family members and 2 patients with Werner’s syndrome were analyzed for the proportion of total T cells and T cells with receptors for I g M (Tμ) or I g G (Tγ). In 3 patients proportions of Tμ cells were within the range for age...

...Tomohiro Nakayama; Toyoko Ochiai; Yoshiko Takahashi; Kimie Ohkubo; Takashi Hironaga; Shinichiro Kokubun Background: Werner’s syndrome, a rare autosomal recessive disorder, is characterized by features of premature aging. Seventy-five percent of the alleles of Japanese patients with Werner’s...

...Manabu Tanabe; Makoto Goto Background: There is a well-established association between Werner’s syndrome (WS) and hyperhyaluronic aciduria; however, to date hyaluronan (HA) in the serum has not been statistically linked with WS. Recently, the gene that causes WS has been defined as a DNA helicase...