...Carmelo Lafuente-Lafuente; Antonio Rainone; Olivier Guérin; Olivier Drunat; Claude Jeandel; Olivier Hanon; Joël Belmin; for the C-VENH (COVID-19 Vaccine Effectiveness in Older Patients) Investigators Background: It is not known if widespread vaccination can prevent the spread of severe acute...

...Martina Prelog Primary prevention strategies, such as vaccinations at the age extremes, in neonates and elderly individuals, demonstrate a challenge to health professionals and public health specialists. The aspects of the differentiation and maturation of the adaptive immune system, the functional...

...Alexander C. Maue; Laura Haynes Age-related declines in immune function are associated with reduced humoral responses following vaccination or infection. Central to this defect is a decline in naïve CD4+ T cell function. In this review, we discuss factors intrinsic and extrinsic to the CD4+ T cell...

... Health Service and others recommend that all persons 65 years of age and older as well as other persons with high-risk conditions receive annual influenza vaccination. Despite these recommendations, 40% or more of high-risk persons fail to receive influenza vaccine. Among the barriers to successful...

... vaccines in eligible, hospitalised subjects aged 65 years or more, admitted between May and September 1998 to a Melbourne hospital. Unvaccinated participants were allocated randomly to alert systems for hospital staff or community general practitioners (GPs). Follow-up occurred at 1 and 3 months...