... and associated with comorbidities. Testosterone is implicated in regulating metabolic functions, maintenance of muscle and bone, and inhibition of adipogenesis. In older individuals, reduced testosterone is thought to contribute to an altered state of metabolism, loss of muscle and bone, and increased fat...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Demography Humans Lifespan Testosterone Dear Sir, Explaining the differences in life span between men...

... Testosterone National Institutes of Health (NIH) 10.13039/100000002 Table 2 Diagnostic criteria for sarcopenia Muscle mass is determined by the balance between pathways favoring protein synthesis and breakdown. The best-defined anabolic pathway leading to protein synthesis...

...Juuso I. Mäkinen; Ilpo Huhtaniemi Background: Normal testicular function is essential for the maintenance of male physical strength and behaviour irrespective of age. A new term of late-onset hypogonadism (LOH) has been coined for the condition of decreased testosterone (T) and hypogonadal symptoms...

... at the hypochondria were needled for the Pn group. Mice in the other 2 groups were grasped using the same method as for the Pa group. The serum testosterone and osteocalcin (OC) levels were determined by radioimmunoassay. The histomorphometric data were obtained from undecalcified specimens, and the mechanical...

...-month-old). Blood testosterone levels begin to decline between the age of 12 and 18 months and remained low from 18 months of age on. These results indicate: (1) deficiencies in the LH regulatory mechanism in response to removal of gonadal steroids are easier to manifest than those of FSH control...

... found in those sites of extrahypothalamic vasopressin (VP) fiber termination that are testosterone-dependent. In the present study, further evaluation of these changes was performed in male Brown-Norway (BN/BiRij) rats. Immunocytochemical staining of VP binding sites in renal tubuli of the senescent, 33...

...H.K. Hsu; C. Hsu; John Y.L. Yu; M.T. Peng Various parameters of copulatory behavior were examined in intact and castrated testosterone-(T-)treated male rats of various ages ranging from 3 to 27 months. Serum T levels were controlled by subcutaneous implantation of different sizes of T-filled...

... with IGF-1 levels similar to young ones do not show the age-dependent decrease in serum testosterone and lean body mass, nor the increase in fat body mass. Other hormone-metabolic and nutritional parameters do not reveal any change compared with the results of all individuals. In females, the results do...