...A.N. Davison Even in nonfamilial cases of dementia there is some evidence of a genetic factor. This may be linked to defective expression of neurofilament protein and also abnormal phosphorylation of cytoskeletal proteins. In this respect there may be a link with accumulation of tangles and amyloid...

... Dementia and Normal Old Age J. Ulricha, H.B. Stähelinb »Neuropathologie Division, Department of Pathology, and bGeriatric Clinic, Kantonsspital Basel, Switzerland Key Words. Alzheimer s disease Senile dementia Plaques Tangles Abstract. Alzheimer neurofibrillary changes and senile plaques were found...