.... Finally, the expression of serotonin signaling and aging-related genes was investigated to explore the underlying mechanism, and the lifespan assays were performed in ser-7 RNAi strain, daf-2 , daf-16 , and aak-2 mutants. Results: Sertraline extended the lifespan in C. elegans with concomitant extension...

... hypothalamic-pituitary-adrenal (HPA) axis activity, serotonergic transmission and hippocampal neurogenesis (perhaps via their effects on serotonin and HPA activity). These data tempt speculation that polyphenolic compounds could also combat age-related cognitive decline, which is often accompanied...

... in young and aged rats and suggest that the age-related reduction in rCMRglc responses to acute MCPP in non-pretreated animals may be due to compensation for age-related losses of 5-HT terminals. 30 08 1992 21 05 1993 14 4 2009 [14C]2-deoxyglucose Serotonin Meta-chlorophenyl...

...W. Birkmayer; J.D. Birkmayer Disorders of neurotransmitter balance are observed in Parkinson’s disease, pharmacotoxic psychosis and depression. The dopamine-serotonin ratio is reduced to about 20% in Parkinson and pharmacotoxic patients in the caudate nucleus and in the substantia nigra...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Brain neurotransmitters Dopamine Noradrenaline Serotonin Acetylcholine Aging Dementia Alzheimer’s disease Hippocampus Autoxidation Gerontology 33: 159-167 (1987) © 1987 S...

...V.D. Petkov; V.V. Petkov; S.L. Stancheva In experiments on 2-, 10- and 22-month-old rats it was found that the B max values of dopamine (DA 2 ), serotonin (5-HT 1 ) and enkephalin (Enk) receptors as well as th( 5-HT level in the three brain regions (cortex, striatum and hypothalamus) decreased...

... Serotonin Gerontology 26: 270 -275 (1980) Effects of Centrally and Systemically Administered ¿-Tyrosine and ¿-Leucine on Ovarian Function in the Old Rat R.L. Cooper and M. Linnoila Center for the Study of Aging and Human Development, and Department of Psychiatry, Duke University Medical Center, Durham...

... (norepinephrine and dopamine), but not serotonin (5-HT) changed with aging in the several brain regions, but only 5-HT was significantly changed (elevated) by ECS. Protein synthesis was significantly inhibited by ECS, notably in limbic structures. The increased susceptibility of aging mice to the amnesic effect...

...Adarsh M. Kumar; Sharlene Weiss; Jesus B. Fernandez; Dean Cruess; Carl Eisdorfer Serotonin has been implicated to play an important role in regulating emotions and behavior, and it is well accepted that the platelet serotonergic system mirrors the presynaptic central serotonergic system. Since...