... of the fundamental bioenergetic mechanisms as drivers of age-related changes in brain structure and function. We sketch out a model that builds on the conceptualization of aging as an expression of cumulative cellular damage inflicted by reactive oxygen species and ensuing declines in energy metabolism. We outline...

..., instructions or products referred to in the content or advertisements. Free radicals Aging Biomarkers Reactive oxygen species Inflammation In recent years, oxidative stress (OS) and inflammatory biomarkers have been postulated to be important factors in the development of age-related diseases...

... of deleterious reactive oxygen species (ROS) via deacetylation and activation of SOD2 (mitochondrial superoxide dismutase) and IDH2 (isocitrate dehydrogenase 2) [ 7,8,9 ]. Through modification of these two targets, SIRT3 reduces cellular ROS levels, thereby protecting nuclear and mitochondrial DNA and other...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Mitochondria Aging Reactive oxygen species Protein quality control...

... models. Exp Gerontol 2009;44:256–260. 39. Pan Y: Mitochondria, reactive oxygen species, and chronological aging: a message from yeast. Exp Gerontol 2011;46:847–852. 40. Cunningham JT, Rodgers JT, Arlow DH, Vazquez F, Mootha VK, Puigserver P: mTOR controls mitochondrial oxidative function through...

... by reducing free radical-induced damage. Increased production of oxygen-derived free radicals plays an important role in the process of aging. Reactive oxygen species are generated by different intracellular molecular pathways principally located in the cytoplasm and in the mitochondria. The mitochondrial...

... cellular removal and seems necessary for the recognition of senescent erythrocytes. Cellular deformability decreases while fragility to hemolytic factors generally increases and surface charge density does not alter. Perhaps more important are reactions of reactive oxygen species with membrane constituents...

... and Schiff’s bases, total antioxidant activity, the activities of Cu/Zn superoxide dismutase, glutathione S-transferase, and glutathione peroxidase, and the generation of reactive oxygen species (ROS) were studied in brain and liver homogenates and in the serum. Results: The controls exposed to pair feeding...

... that the sum of deleterious free radical reactions going on continuously throughout cells and tissues constitutes the aging process or is a major contributor to it. Objective: The aim of this paper was to study the correlation between NADPH oxidase and protein kinase C (PKC) in the reactive oxygen species (ROS...

... to decreased hepatic blood flow. Ultrastructural analysis of the human liver has revealed that the integrity of mitochondria and enzymatic activity remain mostly unchanged with aging. Reactive oxygen species (ROS) are involved in the aging process and result mainly from nonenzymatic processes in the liver...

... Lipid peroxidation Reactive oxygen species Aging Experimental Section Gerontology 1999;45:136 142 Received: May 21, 1997 Accepted: February 16, 1998 Interleukin-1 Induces Lipid Peroxidation and Membrane Changes in Rat Hippocampus: An Age-Related Study C.A. Murraya M.P. Clementsb M.A. Lyncha...