... mechanism for death of large neurons within the CNS. Although tangles are found in several other dementing conditions (e.g. dementia puglistica, Parkinson-dementia complex of Guam), Alzheimer-type plaques and tangles are not invariably found in cases of cognitive deficit. For example, in dementia...

..., and caudatus in autoptic material from patients with senile dementia of Alzheimer type and of mixed vascular-Alzheimer pathogenesis. Different patterns of changes in ligand binding were found for the two groups. Some of these changes were quantitatively correlated with the histological scores of plaques...

...J. Ulrich; H.B. Stähelin Alzheimer neurofibrillary changes and senile plaques were found in a variety of distribution patterns and intensities in 50 brains of patients older than 73 years who had been carefully examined for signs of organic dementia in a geriatric unit. As noted by earlier...