...Shiping He; Shihan Wang; Ruizhou Liu; Hui Chen; Qiang Wang; Dazhou Jia; Longchi Chen; Jihang Dai; Xiaolei Li Introduction: Osteoarthritis (OA) is a prevalent clinical chronic degenerative condition characterized by the degeneration of articular cartilage. Currently, drug treatments for OA come...

...Rami Eltaraboulsi; Amanda E. Nelson; Carolina Alvarez; Jordan B. Renner; Catherine Bowen; Lucy S. Gates; Yvonne M. Golightly Introduction: The aim of this study was to examine the incidence and progression of foot osteoarthritis (OA), as well as associated factors, in a community-based cohort...

...Mengjie Zeng; Flavia Cicuttini; Yuan Z. Lim; Katherine Samaras; Henry Brodaty; Perminder S. Sachdev; John D. Crawford; Yuanyuan Wang Introduction: The data are limited for the association between osteoarthritis (OA) and cardiovascular disease (CVD) in community-based older populations and whether...

...Shi Shi; Lele Zhang; Qi Wang; Qian Wang; Dejian Li; Wei Sun; Chengqing Yi Introduction: Osteoarthritis (OA) is the most prevalent and debilitating joint disease without an effective therapeutic option. Multiple risk factors for OA have been identified, including abnormal chondrocyte miRNA secretion...

...Chengyuan Zhang; Ye Lu; Feng Yuan; Shilin Jiang Objective: CircCCDC66 is involved in cancer progression, but its role in osteoarthritis (OA) remains unknown. This study was carried out to explore the biological role of circCCDC66 in OA and its underlying mechanism. Methods: The expression levels...

...Mingcai Zhang; Justin L. Theleman; Katherine A. Lygrisse; Jinxi Wang Aging is a progressive and complicated bioprocess with overall decline in physiological function. Osteoarthritis (OA) is the most common joint disease in middle-aged and older populations. Since the prevalence of OA increases...

...Christopher Kim; Armand Keating Osteoarthritis (OA) is designated the 11th highest contributor of 291 diseases of global disability and the most common cause of chronic disability in elderly people. OA has a devastating impact on quality of life and represents an enormous socio-economic burden...

... and progression of arthritic and musculoskeletal diseases. Indeed, aging and inflammation (often referred to as ‘inflammaging') are critical risk factors for the development of osteoarthritis (OA), which is one of the most common forms of joint disease. The term ‘chondrosenescence' has recently been introduced...

...Allen J. Bailey; Jason P. Mansell Research into the aetiology of osteoarthritis has for several decades been concentrated on the destruction of the articular cartilage, the initiating events being believed to be changes in the proteoglycans and subsequently in the supporting collagenous framework...

... occupations was correlated to radiographic osteoarthritis of the distal interphalangeal joint classes II-V in females and of the metacarpophalangeal joint class I in males, but not to radiographic or clinical osteoarthritis in knee joints. The prevalence of rheumatoid arthritis was not significantly different...

...A. Black; M.A. Lane Background: Bone loss, osteoarthritis (OA) and age-related changes in reproduction are some of the most apparent and troubling results of advancing age in the human population. The significance of these changes underscores the need for developing appropriate animal models...