... years) and 49.21% females. With confounders controlled, compared to normal or overweight (23 ≤ BMI <30), an adjusted OR of 1.23 (95% CI: 1.18, 1.29) on inferior mental health status was detected for the underweight group (BMI <23) significantly. Adjusted OR for those obese (BMI ≧30) was 0.87 (95...

... obesity (based on waist circumference [WC]) were associated with a 17-year mortality risk in community-dwelling older adults. Methods: Participants were 2,017 community-dwelling adults aged 65 years or above in the longitudinal Enquête de Santé Psychologique-Risques, Incidence et Traitement study. Self...

...Yuxin Hu; Caixia Xia; Hao Chen; Wenjun Song; Quanxiang Zhou; Xing Yang; Jingyuan Yang Background: Early identification of risk factors for cognition decline may contribute to the interventions for Alzheimer’s disease. Obesity is a common modifiable risk factor for chronic diseases. The association...

...Kelli L. Vaughan; Julie A. Mattison The prevalence of obesity in the US is increasing exponentially across gender, age and ethnic groups. Obesity and a long-term hypercaloric diet result in what appears to be accelerated aging, often leading to a multi-systemic deterioration known as the metabolic...

.... In women, the positive though slight effect of MetS on BMD could not be explained by single MetS components apart from IR. In men, central obesity was negatively associated with BMD, suggesting that the metabolic effects driven by visceral fat have a negative impact. © 2016 S. Karger AG, Basel 2016...

...Meng-Yueh Chien; Li-Ying Wang; Hsi-Chung Chen Background: Numerous studies have reported the relationship between sleep duration and obesity in elderly adults; however, little is known about the relationship of sleep duration and sarcopenia. Objective: We examined the relationship of sleep duration...

... to diet-induced obesity, dyslipidemia, atherogenesis, hepatic steatosis, and macrophage infiltration/activation in adipose tissue and skeletal muscle [ 28,29 ](fig. 1 ). Third, myostatin is a very drugable protein given it is secreted, and therefore, accessible in the circulation. This characteristic...

... different teleological purposes. The molecular understanding of their physiological pathways opens the door to the development of a rational pharmacotherapy of obesity and associated disorders. Thus, the targeting of energy expenditure in brown adipose tissue may be an attractive alternative strategy...

...Éric Le Bourg In their response to my letter to the editor, Drs. Gavrilova and Gavrilov disagree with some of my arguments and argue that dietary restriction studies in humans ‘should not be dismissed as a valid tool to extending life span in non-obese individuals’. I would now like to answer...

... increased longevity in Okinawa inhabitants, and thus that DR can increase longevity in humans. The purpose of this article is to stress that no data on humans with a normal body mass index (neither overweight nor obese) indicate that DR can increase life span and health span, particularly because...

... mellitus has been discussed, there is very little information on MetS-type cardiometabolic risk factor clustering in diabetic elderly. Objective: To determine the relationship among age-associated changes in obesity, insulin resistance, and clustering of MetS-type risk factors, in association with vascular...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Glucose transport GLUT-4 Glucose Obesity Experimental Section Gerontology 1995;41:205-211 R. Jam es Barnard JackF...

...Maximilian Zeyda; Thomas M. Stulnig The association of obesity, insulin resistance, and chronic low-grade inflammation has been evident for several years by now. Since obesity, insulin resistance, and inflammation all are related to aging as well, the mechanisms underlying this association...

...Nobuhiro Morisaki; Mikihiko Kawano; Satoe Watanabe; Yasushi Saito; Sho Yoshida The influence of obesity on the development of ischemic heart disease (IHD) was studied in 103 diabetic patients over 65 years of age. The patients were divided into three groups on the basis of their body mass index...

...M. Verdy; H.P. Levesque; D. Boghen; M. Aube; J. Guimond A manual dexterity test was performed in a population of elderly women. Obese subjects with hyperostosis frontalis interna (HFI) had a poorer performance than subjects with either HFI alone or obesity alone. The combined effects of cerebral...

... lower; the CBA/ORT mice represent a normal laboratory strain which rarely suffers from osteoarthrosis. In terms of the weight of readily removable subcutaneous and abdominal adipose tissue, the male STR/ORT mice were slightly leaner than the male CBA/ORT mice, the female STR/ORT mice were obese when...

...Ruth Silberberg In male mice of strain C 57 Bl, obesity caused by intraperitoneal administration of aurothioglucose failed to alter the course of spontaneous osteoarthrosis. The distribution of osteoarthrosis of the knee joint and of spondylosis of the thoracic and lumbar spine was haphazard...

...Monika Lechleitner The metabolic syndrome is defined as a cluster of cardiometabolic risk factors which are related to insulin resistance. Beyond the importance of each separate risk factor, the aggregation of abdominal obesity, impaired glucose metabolism, dyslipidemia and hypertension, summarized...

...Shivani Dewan; John P.H. Wilding Type-2 diabetes is common in the elderly and when compounded by obesity presents a major challenge for the physician. Obesity plays a central role in the aetiology and pathogenesis of type-2 diabetes. Body weight is determined by an interaction between genetic...