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Keywords: Mitochondria
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Journal Articles
Journal Articles
Journal: Gerontology
Gerontology (2016) 62 (5): 513–518.
Published Online: 01 April 2016
... Senescence-associated secretory phenotype Skin regeneration Aging DNA damage Therapy Mitochondria Drugs Immune system Cellular senescence is a tumor-suppressive mechanism wherein cells are permanently growth arrested even in the presence of strong mitogenic signals [ 1 ]. Cells are induced...
Journal Articles
Journal: Gerontology
Gerontology (2015) 61 (4): 343–349.
Published Online: 20 December 2014
... are, at the same time, also markers of mitochondrial aging and cell senescence. Changes in mitochondria are well known to occur during aging [ 14,15,16 ]. The most prominent signs of mitochondrial aging are the structural alterations to this organelle as well as mtDNA damage [ 17,18,19 ]. mtDNA has been...
Journal Articles
Journal: Gerontology
Gerontology (2015) 61 (2): 139–148.
Published Online: 06 December 2014
... with advanced age plays a central role in the development of sarcopenia due to the multifactorial functions of this organelle in energy supply, redox regulation, crosstalk with nuclear gene expression and apoptosis. In order to fulfill these roles, it is crucial that mitochondria maintain their own structural...
Journal Articles
Journal: Gerontology
Gerontology (2015) 61 (2): 131–138.
Published Online: 13 November 2014
... to in the content or advertisements. T cells Aging Mitochondria Metabolism Aging of the immune system is a major risk factor for increased morbidity and mortality of the elderly. This gradual deterioration occurs with natural age advancement and thus affects the entire population. The aging immune...
Journal Articles
Journal: Gerontology
Gerontology (2014) 60 (2): 174–182.
Published Online: 20 February 2014
...Raul Bukowiecki; James Adjaye; Alessandro Prigione Mitochondria are organelles playing pivotal roles in a range of diverse cellular functions, from energy generation to redox homeostasis and apoptosis regulation. Their loss of functionality may indeed contribute to the development of aging and age...
Journal Articles
Journal: Gerontology
Gerontology (2013) 60 (1): 56–64.
Published Online: 25 October 2013
... of the mitochondria is communicated to the rest of the cell, and to the organism overall. 13 05 2013 16 07 2013 25 10 2013 © 2013 S. Karger AG, Basel 2013 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages...
Journal Articles
Journal: Gerontology
Gerontology (2013) 59 (5): 413–420.
Published Online: 18 April 2013
...Heinz D. Osiewacz; Dominik Bernhardt A fundamental impact of mitochondria on biological aging has been suggested decades ago. One prominent theory explains aging as the result of the age-related accumulation of random molecular damage of biomolecules resulting from the reaction of reactive oxygen...
Journal Articles
Journal: Gerontology
Gerontology (2012) 58 (2): 99–106.
Published Online: 23 September 2011
... if downregulating myonuclear apoptosis is effective in maintaining muscle mass and function in late life, identify the most relevant apoptotic pathway(s) to target, and determine the optimal timing for intervening. 7 04 2011 9 06 2011 23 9 2011 Muscle Mitochondria Calorie restriction...
Journal Articles
Journal Articles
Journal: Gerontology
Gerontology (2010) 56 (6): 544–552.
Published Online: 17 March 2010
... Mitochondria Hypoxia and aging Rat heart Abstract Background: Hypoxia and aging determine on mammalian cells a stress response which implies modified production of oxidants, reactive oxygen species or reactive nitrogen species at the mitochondrial level, interfering with cell-signaling proteins...
Journal Articles
Journal: Gerontology
Gerontology (1995) 41 (Suppl. 2): 259–270.
Published Online: 15 April 2009
... c Mitochondria Lysosomes Proteolysis Ceroid-lipofuscin Batten disease © 1995 S. Karger AG, Basel 1995 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any...
Journal Articles
Journal: Gerontology
Gerontology (1993) 39 (1): 7–18.
Published Online: 14 April 2009
... Research Laboratory. Chicago Medical School. University of Health Sciences, North Chicago. 111.. USA; Department of Physiology. University of Texas Health Science Center at San Antonio. Tex.. USA Keywords Fatty acids Aging Food restriction A9-Desaturase Fischer 344 rats Peroxidizability Mitochondria...
Journal Articles
Journal: Gerontology
Gerontology (1992) 38 (4): 192–195.
Published Online: 08 April 2009
... as compared to males. In whole body homogenates, propyl gallate (PG; 25 µg/ml) increased the glutathione content significantly up to the 22nd day of life whereas in mitochondria it increased during all age intervals in the two sexes with the exception of the 36th and 43rd day of survival in males...
Journal Articles
Journal: Gerontology
Gerontology (1982) 28 (6): 354–359.
Published Online: 06 April 2009
...Hans Nohl Morphological changes in rat heart mitochondria following mobilization of the adenine nucleotide binding sites from the matrix to the cytosolic face of the inner membrane have been documented in this paper by means of electron microscopy. Significant differences in the shape of cristae...
Journal Articles
Journal: Gerontology
Gerontology (1976) 22 (4): 334–362.
Published Online: 03 April 2009
... in mitochondria and/or mitochondrial enzyme systems, myofibrils, as well as other biochemical systems have been sufficiently documented in a number of species, directly correlated with the attainment of optimal flight ability in terms of both wing beat frequency and the duration of sustained flight, suggesting...
Journal Articles
Journal: Gerontology
Gerontology (1998) 44 (2): 78–84.
Published Online: 13 February 1998
... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 13 2 1998 Ascorbate Mitochondria Fibroblasts Experimental Section Gerontology 1998;44:78 84 Received: June 28, 1996 Accepted: October...