...S.C. Khanna; S.K. Garg; Suraj P. Sharma The glutathione reductase activity was estimated in brain and liver of male mice of different age groups fed on butylated hydroxy anisole (BHA), propyl gallate (PG) and α-tocopherol (TP). A significant increase in glutathione reductase activity was observed...

...Harold R. Massie; Valerie R. Aiello; Leslie K. DeWolfe Male C57BL/6J mice ranging in age from 50 to 1186 days were used to measure total calcium and calmodulin concentrations. The increase in calcium between 0 and 1,000 days of age was 260% for kidney, followed by brain (189%), heart (173.5%), lung...

...Katsumaro Kurumado; Tatsuo Yamakawa Correlation between advance of age and changes of basal lamina width of mucosal epithelium and capillary was estimated in both the fundic gland and the pyloric gland, respectively, by electron-microscopic morphometry, using C57BL/6N mice. In basal lamina width...

...Harold R. Massie; Valerie R. Aiello; Timothy J. Doherty Feeding C57BL/6J male mice 1% ascorbic acid (1,430 mg/kg body weight) in their drinking water for life increased the average life span by 8.6% (p < 0.05) and perhaps by as much as 20.4%. The ascorbic acid group weighed 6–7% less than...

...Carol M. Warner; Carol J. Briggs; Doris Balinsky; Terry E. Meyer Glucose phosphate isomerase (GPI) enzyme activity was measured in two strains of mice, A/HeNNia1 ( Gpi -1 a ) and C57BL/6NNia1 ( Gpi -1 b ). Seven solid tissues (muscle, brain, heart, kidney, liver, lung, spleen) and three cell types...

...R.J. Feuers; R.R. Delongchamp; S. Kramer; L.E. Scheving; D.A. Casciano Mice were standardized to 12 h of light exposure alternating with 12 h of darkness and were fed ad libitum. The mice in the first group were 8 weeks old and in the other 104–116 weeks old. Subgroups of 7 animals from each age...

...Walter B. Essman Aging mice showed a retrograde amnesia for passive avoidance behavior when a single electroconvulsive shock (ECS) was given at post-training intervals up to 1 h, whereas adult mice showed no significant amnesia when ECS was given 10 min or more after training. Catecholamines...

...Katsuiku Hirokawa; Masanori Utsuyama; Hiroshi Goto; Kazunao Kuramoto Immunological studies were performed in aging C57BL/6 and BDF 1 mice. In C57BL/6 mice the incidence of malignant tumor was high and their mean life span was 665 days in males and 649 days in females. In BDF 1 mice, the incidence...

...Vladimir M. Dilman; Vladimir N. Anisimov The chronic treatment of female C3H/Sn mice with phenformin (2 mg/day) and diphenylhydantoin (2 mg/day) prolonged mean life span by 23 and 25%, respectively, and decreased spontaneous tumour incidence by 4.0 and 2.3 times, respectively. The chronic treatment...

...Patricia D. Wilson In the livers from young (3–6 month) and old (30 month) C57/BL mice and BN/Bi rats light microscope histochemistry has shown that enzyme activity is not always distributed evenly throughout the lobule. The mitochondrial enzyme succinic dehydro-genase, the plasma membrane enzyme 5...

... with the mean longevity of the control group. Although obese mice ( ob ) had a shorter life span than other mutant groups, mice which also attained a very high body weight (yellow, A y ) did not differ significantly in longevity from thin mutant mice. Moreover, peak body weight was positively correlated...

...H. Finger; B. Heymer; P. Emmerling; H. Hof The secondary antibody-forming potential of non-splenic lymphatic tissues during senescence was investigated in NMRI/Han mice, both at the cellular and humoral levels. The mean life span of conventionally reared NMRI/Han mice amounts to 19.86 months. After...

... of various neuroendocrine peptides were determined by radioimmunoassays in tissue extracts from the antrum, duodenum and colon of mice in four different age groups: 1, 3, 12 and 24 months. The neuroendocrine peptides investigated were: secretin, gastric inhibitory polypeptide (GIP), gastrin, motilin, peptide...