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Keywords: Methylglyoxal
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Journal Articles

Aging-Dependent Reduction in Glyoxalase 1 Delays Wound Healing

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Subject Area:
Topic Article Package: Diabetes , Geriatrics and Gerontology
Thomas H. Fleming, Till-Martin Theilen, Jinit Masania, Marius Wunderle, Jamshid Karimi, Spiros Vittas, Rainer Bernauer, Angelika Bierhaus, Naila Rabbani, Paul J. Thornalley, Jens Kroll, Jens Tyedmers, Ralph Nawrotzki, Stephan Herzig, Michael Brownlee, Peter P. Nawroth
Journal: Gerontology
Gerontology (2013) 59 (5): 427–437.
https://doi.org/10.1159/000351628
Published Online: 22 June 2013
...Thomas H. Fleming; Till-Martin Theilen; Jinit Masania; Marius Wunderle; Jamshid Karimi; Spiros Vittas; Rainer Bernauer; Angelika Bierhaus; Naila Rabbani; Paul J. Thornalley; Jens Kroll; Jens Tyedmers; Ralph Nawrotzki; Stephan Herzig; Michael Brownlee; Peter P. Nawroth Methylglyoxal (MG), the major...
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Journal Articles

Reactive Metabolites and AGE/RAGE-Mediated Cellular Dysfunction Affect the Aging Process – A Mini-Review

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Subject Area:
Geriatrics and Gerontology
Thomas H. Fleming, Per M. Humpert, Peter P. Nawroth, Angelika Bierhaus
Journal: Gerontology
Gerontology (2011) 57 (5): 435–443.
https://doi.org/10.1159/000322087
Published Online: 21 October 2010
... reactive physiological relevant glycating agents, are the dicarbonyls, in particular methylglyoxal. Endogenously formed dicarbonyl compounds can react with proteins to form advanced glycation endproducts (AGEs). Experimental models have recently provided evidence that reduced detoxification of AGE...
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